RIBAVIRIN

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC J05AP01
UNII 49717AWG6K
EPA CompTox DTXSID8023557

Structure

InChI Key IWUCXVSUMQZMFG-AFCXAGJDSA-N
Smiles NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1
InChI
InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H12N4O5
Molecular Weight 244.21
AlogP -3.01
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 3.0
Polar Surface Area 143.72
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 17.0

Pharmacology

Mechanism of Action Action Reference
Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor INHIBITOR PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase GSK family
- - - - 33.3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor
- - - - 0-23
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 87.39-112.33
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Bos taurus
670 - - - -
Chikungunya virus
- - - - 10-97
Cricetulus griseus
- - - - 87.39-112.33
Dengue virus
- - - - 75
Dengue virus 2
- - - - 32.03-67.47
Dengue virus 2 Thailand/16681/84
- - - - 10.14-32.53
Hantaan virus
- - - - -80-99.9
Hepatitis C virus
- 40 - - 31.2-65.74
Hepatitis C virus subtype 1a
- - - - 32-50
Hepatitis C virus subtype 1b
- - - - 44
Homo sapiens
- - - - 0-70
Infectious hematopoietic necrosis virus
- - - - 99.07
Influenza A virus
- 410 - - -
Influenza A virus (A/WSN/1933(H1N1))
- - - - 85.47
Influenza B virus (B/Hong Kong/05/1972)
94-140 - - - -
Mus musculus
- - - - 0-80
Potato virus X
- - - - 94
Rattus norvegicus
- - - - 75
Tobacco mosaic virus
- - - - 7.5-41
West Nile virus
- - - - 90
Zika virus
- - - - 37-93
influenza A virus
- 2 - - -

Target Conservation

Protein: Inosine-5'-monophosphate dehydrogenase 1
Description: Inosine-5'-monophosphate dehydrogenase 1
Organism : Homo sapiens
P20839 ENSG00000106348

Related Entries

Cross References

Resources Reference
ChEBI 63580
ChEMBL CHEMBL1643
DrugBank DB00811
DrugCentral 2373
FDA SRS 49717AWG6K
Human Metabolome Database HMDB0014949
Guide to Pharmacology 6842
PDB RBV
PharmGKB PA451241
PubChem 37542
SureChEMBL SCHEMBL3727
ZINC ZINC000001035331
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