REPAGLINIDE


Trade Names	PRANDIN REPAGLINIDE
Synonyms	A10BX02 AG-EE 623 ZW AG-EE-623-ZW AG-EE-623ZW AGEE-623ZW Enyglid NSC-759893 Novonorm Prandin Repaglinide
Status
Molecule Category	Free-form
ATC	A10BX02
UNII	668Z8C33LU
EPA CompTox	DTXSID3023552


InChI Key	FAEKWTJYAYMJKF-QHCPKHFHSA-N
Smiles	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O
InChI	InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1

Mechanism of Action	Action	Reference
Sulfonylurea receptor 1, Kir6.2 blocker	BLOCKER	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	42.2-88.4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	76.4
Transporter Electrochemical transporter	-	-	-	-	42.2-88.4
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	-	-	-	35
Transporter Primary active transporter ATP-binding cassette ABCC subfamily	-	106	50	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	106	50	-	35-88.4
Mus musculus	-	-	-	-	66.1
Rattus norvegicus	-	-	-	-	96.16-99.05
Staphylococcus aureus	-	-	-	-	14


Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-binding cassette sub-family C member 8 Organism : Homo sapiens Q09428 ENSG00000006071












Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-sensitive inward rectifier potassium channel 11 Organism : Homo sapiens Q14654 ENSG00000187486

CONTENTS