QUINIDINE SULFATE


Trade Names	CIN-QUIN QUINIDEX QUINIDINE SULFATE QUINORA
Synonyms	AVP-786 COMPONENT QUINIDINE SULFATE Cin-quin NSC-10004 QUINIDINE SULFATE COMPONENT OF AVP-786 Quinicardine Quinidex Quinidex extentabs Quinidine sulfate Quinidine sulfate anhydrous Quinidine sulfate dihydrate Quinidine sulfate hydrate Quinidine sulphate Quinidine sulphate anhydrous Quinidine sulphate dihydrate Quinidine, sulfate (2:1) (salt)
Status
Molecule Category	Salt-form
UNII	J13S2394HE
Parent Compound:	QUINIDINE


InChI Key	ZHNFLHYOFXQIOW-AHSOWCEXSA-N
Smiles	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12.C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O
InChI	InChI=1S/2C20H24N2O2.H2O4S.2H2O/c21-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h23-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);21H2/t213-,14-,19+,20-;;;/m00.../s1

Mechanism of Action	Action	Reference
Sodium channel alpha subunit blocker	BLOCKER	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	20-20	-	-	-
Enzyme Phosphatase	-	-	-	-	19
Enzyme	-	20-20	-	-	19

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	29.68
Homo sapiens	-	20-20	-	-	5-19
Plasmodium falciparum	-	25.12-158.49	-	-	-
Plasmodium falciparum 7G8	-	39.81	-	-	-
Plasmodium falciparum D10	-	19.95	-	-	-
Plasmodium falciparum HB3	-	39.81	-	-	-


Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314












Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873








Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253









Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876











Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313

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