EcoDrugPlus


Trade Names	HYDROMOX
Synonyms	Chinethazone Hydromox NSC-759904 Quinethazone
Status
Molecule Category	Free-form
ATC	C03BA02
UNII	455E0S048W
EPA CompTox	DTXSID9023548


InChI Key	AGMMTXLNIQSRCG-UHFFFAOYSA-N
Smiles	CCC1NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2N1
InChI	InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)

Property Name	Value
Molecular Formula	C10H12ClN3O3S
Molecular Weight	289.74
AlogP	0.88
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	101.29
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor	INHIBITOR	DOI

Resources	Reference
ChEBI	8717
ChEMBL	CHEMBL1532
DrugBank	DB01325
DrugCentral	2343
FDA SRS	455E0S048W
Human Metabolome Database	HMDB0015420
Guide to Pharmacology	7289
KEGG	C07342
PharmGKB	PA164760863
PubChem	6307
SureChEMBL	SCHEMBL301310
ZINC	ZINC00896838

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

QUINETHAZONE

Structure

Physicochemical Descriptors

Pharmacology

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