PYRAZINAMIDE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC J04AK01
UNII 2KNI5N06TI
EPA CompTox DTXSID9021215

Structure

InChI Key IPEHBUMCGVEMRF-UHFFFAOYSA-N
Smiles NC(=O)c1cnccn1
InChI
InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)

Physicochemical Descriptors

Property Name Value
Molecular Formula C5H5N3O
Molecular Weight 123.11
AlogP -0.42
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 68.87
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 9.0

Pharmacology

Mechanism of Action Action Reference
70S ribosome inhibitor INHIBITOR PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 79.24-116.57
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 79.24-116.57
Mycobacterium tuberculosis
- - - - 6-100
Mycobacterium tuberculosis H37Rv
- - - - 99-100

Cross References

Resources Reference
ChEBI 45285
ChEMBL CHEMBL614
DrugBank DB00339
DrugCentral 2328
FDA SRS 2KNI5N06TI
Human Metabolome Database HMDB0014483
Guide to Pharmacology 7287
KEGG C01956
PDB PZA
PharmGKB PA451182
PubChem 1046
SureChEMBL SCHEMBL24102
ZINC ZINC000000002005
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