PROPOXYPHENE HYDROCHLORIDE

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Search structure


Trade Names	DARVON DOLENE KESSO-GESIC PROPHENE 65 PROPOXYPHENE HYDROCHLORIDE PROPOXYPHENE HYDROCHLORIDE 65
Synonyms	Algaphan Darvon Deprancol Dextro propoxyphene hydrochloride Dextropropoxiphene chloride Dextropropoxyphene Dextropropoxyphene hydrochloride Dolene Doloxene Femadol Harmar Kesso-gesic Prophene 65 Propoxyphene hcl Propoxyphene hydrochloride
Status
Molecule Category	Salt-form
UNII	CB2TL9PS0T
EPA CompTox	DTXSID6048913

Structure


InChI Key	QMQBBUPJKANITL-MYXGOWFTSA-N
Smiles	CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C.Cl
InChI	InChI=1S/C22H29NO2.ClH/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;/h6-15,18H,5,16-17H2,1-4H3;1H/t18-,22+;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H30ClNO2
Molecular Weight	375.94
AlogP	4.28
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	8.0
Polar Surface Area	29.54
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	25.0

Pharmacology

Mechanism of Action	Action	Reference
Mu opioid receptor agonist	AGONIST	PubMed DailyMed

Target Conservation


Protein: Mu opioid receptor Description: Mu-type opioid receptor Organism : Homo sapiens P35372 ENSG00000112038

Cross References

Resources	Reference
ChEBI	8498
ChEMBL	CHEMBL1237104
FDA SRS	CB2TL9PS0T
PubChem	15424
SureChEMBL	SCHEMBL9269

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025