None is not found in the database.

PITOLISANT HYDROCHLORIDE

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Search structure


Trade Names	WAKIX
Synonyms	Ciproxidine Pitolisant hydrochloride Wakix
Status
Molecule Category	Salt-form
UNII	YV33CH63HI
EPA CompTox	DTXSID50238098
Parent Compound:	PITOLISANT

Structure


InChI Key	XLFKECRRMPOAQS-UHFFFAOYSA-N
Smiles	Cl.Clc1ccc(CCCOCCCN2CCCCC2)cc1
InChI	InChI=1S/C17H26ClNO.ClH/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19;/h7-10H,1-6,11-15H2;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H27Cl2NO
Molecular Weight	332.32
AlogP	4.17
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	8.0
Polar Surface Area	12.47
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	20.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H3 receptor inverse agonist	INVERSE AGONIST	FDA PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	-	-	27.6	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	27.6	-

Target Conservation


Protein: Histamine H3 receptor Description: Histamine H3 receptor Organism : Homo sapiens Q9Y5N1 ENSG00000101180

Cross References

Resources	Reference
ChEMBL	CHEMBL4164059
FDA SRS	YV33CH63HI
PubChem	11551689
SureChEMBL	SCHEMBL4591893

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025