PILOCARPINE HYDROCHLORIDE

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Search structure


Trade Names	ISOPTO CARPINE PILOCARPINE HYDROCHLORIDE PILOPINE HS SALAGEN
Synonyms	Isopto carpine Ocusert Piloc hcl Pilocarpine hcl Pilocarpine hydrochloride Pilocarpine monohydrochloride Pilocarpini hydrochloridum Pilocarpinum muriaticum Pilogel Pilopine Pilopine hs Salagen Sno pilo Vistacarpin n
Status
Molecule Category	Salt-form
UNII	0WW6D218XJ
EPA CompTox	DTXSID2041096
Parent Compound:	PILOCARPINE

Structure


InChI Key	RNAICSBVACLLGM-GNAZCLTHSA-N
Smiles	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C.Cl
InChI	InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C11H17ClN2O2
Molecular Weight	244.72
AlogP	1.16
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	3.0
Polar Surface Area	44.12
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Mechanism of Action	Action	Reference
Muscarinic acetylcholine receptor M1 agonist	AGONIST	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	1.99-20.03

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Electrophorus electricus	-	-	-	-	20.03
Equus caballus	-	-	-	-	1.99

Target Conservation


Protein: Muscarinic acetylcholine receptor M1 Description: Muscarinic acetylcholine receptor M1 Organism : Homo sapiens P11229 ENSG00000168539










Protein: Muscarinic acetylcholine receptor M3 Description: Muscarinic acetylcholine receptor M3 Organism : Homo sapiens P20309 ENSG00000133019

Cross References

Resources	Reference
ChEBI	141029
ChEMBL	CHEMBL1200330
FDA SRS	0WW6D218XJ
PubChem	5909
SureChEMBL	SCHEMBL21643740

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025