EcoDrugPlus


Trade Names	PERPHENAZINE TRILAFON
Synonyms	Chlorpiprazine Decentan Etaperazine Fentazin NSC-150866 Perphenazine Perphenazine Fendizoate Perphenazine fendizoate Perphenazine maleate Trilafon Trilafon-La
Status
Molecule Category	Free-form
ATC	N05AB03
UNII	FTA7XXY4EZ
EPA CompTox	DTXSID1023441

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SubStructure

Threshold (%) >= 70


InChI Key	RGCVKNLCSQQDEP-UHFFFAOYSA-N
Smiles	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
InChI	InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H26ClN3OS
Molecular Weight	403.98
AlogP	3.94
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	29.95
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	27.0

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed PubMed PubMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	120	-	-	-
Enzyme Oxidoreductase	-	33-740	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	0.3	-	-	99.5-100.2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	-	23	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	113.26-130.02

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	113.26-130.02
Homo sapiens	-	0.3-524.21	-	23	99.5-100.2
Rattus norvegicus	-	740	-	-	-

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295

Cross References

Resources	Reference
ChEBI	8028
ChEMBL	CHEMBL567
DrugBank	DB00850
DrugCentral	2113
FDA SRS	FTA7XXY4EZ
Human Metabolome Database	HMDB0014988
Guide to Pharmacology	209
KEGG	C07427
PharmGKB	PA450882
PubChem	4748
SureChEMBL	SCHEMBL42125
ZINC	ZINC000019228902

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PERPHENAZINE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References