PERGOLIDE MESYLATE


Trade Names	PERGOLIDE MESYLATE PERMAX
Synonyms	Celance LY 127809 LY-127809 NSC-319773 NSC-758442 Pergolide mesilate Pergolide mesylate Pergolide methanesulfonate Permax
Status
Molecule Category	Salt-form
UNII	55B9HQY616
EPA CompTox	DTXSID6040583
Parent Compound:	PERGOLIDE


InChI Key	UWCVGPLTGZWHGS-ZORIOUSZSA-N
Smiles	CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21.CS(=O)(=O)O
InChI	InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1

Mechanism of Action	Action	Reference
Dopamine receptor agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	50-70	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	85.27-90.15

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	85.27-90.15
Rattus norvegicus	-	0.07	-	-	-


Protein: Dopamine receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Dopamine receptor Description: D(1A) dopamine receptor Organism : Homo sapiens P21728 ENSG00000184845












Protein: Dopamine receptor Description: D(4) dopamine receptor Organism : Homo sapiens P21917 ENSG00000069696










Protein: Dopamine receptor Description: D(1B) dopamine receptor Organism : Homo sapiens P21918 ENSG00000169676











Protein: Dopamine receptor Description: D(3) dopamine receptor Organism : Homo sapiens P35462 ENSG00000151577

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