EcoDrugPlus


Trade Names	OSPHENA
Synonyms	(deaminohydroxy) toremifene FC-1271 FC-1271A Ospemifene Osphena Senshio Tore iii
Status
Molecule Category	Free-form
ATC	G03XC05
UNII	B0P231ILBK

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InChI Key	LUMKNAVTFCDUIE-VHXPQNKSSA-N
Smiles	OCCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccccc2)cc1
InChI	InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H23ClO2
Molecular Weight	378.9
AlogP	5.65
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	29.46
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	27.0

Mechanism of Action	Action	Reference
Estrogen receptor modulator	MODULATOR	DailyMed

Target Conservation


Protein: Estrogen receptor Description: Estrogen receptor Organism : Homo sapiens P03372 ENSG00000091831












Protein: Estrogen receptor Description: Estrogen receptor beta Organism : Homo sapiens Q92731 ENSG00000140009

Cross References

Resources	Reference
ChEBI	73275
ChEMBL	CHEMBL2105395
DrugBank	DB04938
DrugCentral	4749
FDA SRS	B0P231ILBK
Guide to Pharmacology	7349
PubChem	3036505
SureChEMBL	SCHEMBL948118
ZINC	ZINC000001550766

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

OSPEMIFENE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References