Trade Names | |
Synonyms | |
Status | |
Molecule Category | Salt-form |
UNII | UBY910DUXH |
EPA CompTox | DTXSID5025815 |
Parent Compound: | ORPHENADRINE |
InChI Key | UQZKYYIKWZOKKD-UHFFFAOYSA-N | |
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Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C18H24ClNO | |
Molecular Weight | 305.85 | |
AlogP | 3.66 | |
Hydrogen Bond Acceptor | 2.0 | |
Hydrogen Bond Donor | 0.0 | |
Number of Rotational Bond | 6.0 | |
Polar Surface Area | 12.47 | |
Molecular species | BASE | |
Aromatic Rings | 2.0 | |
Heavy Atoms | 20.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Glutamate [NMDA] receptor antagonist | ANTAGONIST | PubMed PubMed PubMed |
Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2D Organism : Homo sapiens O15399 ENSG00000105464 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 3B Organism : Homo sapiens O60391 ENSG00000116032 |
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Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546 |
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Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 1 Organism : Homo sapiens Q05586 ENSG00000176884 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2A Organism : Homo sapiens Q12879 ENSG00000183454 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2B Organism : Homo sapiens Q13224 ENSG00000273079 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 2C Organism : Homo sapiens Q14957 ENSG00000161509 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432 |
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Protein: Glutamate [NMDA] receptor Description: Glutamate receptor ionotropic, NMDA 3A Organism : Homo sapiens Q8TCU5 ENSG00000198785 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313 |
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Resources | Reference | |
---|---|---|
ChEBI | 60902 | |
ChEMBL | CHEMBL1201023 | |
FDA SRS | UBY910DUXH | |
Guide to Pharmacology | 7251 | |
KEGG | C07935 | |
PubChem | 9568 | |
SureChEMBL | SCHEMBL1235378 | |
ZINC | ZINC00155269 |