ONDANSETRON HYDROCHLORIDE

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Search structure


Trade Names	ONDANSETRON HYDROCHLORIDE ONDANSETRON HYDROCHLORIDE AND DEXTROSE IN PLASTIC CONTAINER ONDANSETRON HYDROCHLORIDE PRESERVATIVE FREE ZOFRAN ZOFRAN AND DEXTROSE IN PLASTIC CONTAINER ZOFRAN PRESERVATIVE FREE
Synonyms	Demorem GR 38032F GR-38032F NSC-665799 Odansetron hydrochloride Ondansetron (as hydrochloride) Ondansetron hcl Ondansetron hydrochloride Ondansetron hydrochloride dihydrate Ondansetron hydrochloride hydrate Ondansetron hydrochloride preservative free Ondansetron monohydrochloride Ondemet SN 307 SN-307
Status
Molecule Category	Salt-form
UNII	NMH84OZK2B
EPA CompTox	DTXSID9048857
Parent Compound:	ONDANSETRON

Structure


InChI Key	VRSLTNZJOUZKLX-UHFFFAOYSA-N
Smiles	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O.Cl.O.O
InChI	InChI=1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H24ClN3O3
Molecular Weight	365.86
AlogP	3.13
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	2.0
Polar Surface Area	39.82
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 3a (5-HT3a) receptor antagonist	ANTAGONIST	DailyMed

Target Conservation


Protein: Serotonin 3a (5-HT3a) receptor Description: 5-hydroxytryptamine receptor 3A Organism : Homo sapiens P46098 ENSG00000166736

Cross References

Resources	Reference
ChEBI	7774
ChEMBL	CHEMBL3186492
FDA SRS	NMH84OZK2B
PubChem	59774
SureChEMBL	SCHEMBL25018

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025