NICARDIPINE HYDROCHLORIDE


Trade Names	CARDENE CARDENE IN 0.83% SODIUM CHLORIDE IN PLASTIC CONTAINER CARDENE IN 0.86% SODIUM CHLORIDE IN PLASTIC CONTAINER CARDENE IN 4.8% DEXTROSE IN PLASTIC CONTAINER CARDENE IN 5.0% DEXTROSE IN PLASTIC CONTAINER CARDENE SR NICARDIPINE HYDROCHLORIDE NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE
Synonyms	Barizin Cardene Cardene sr Cardepine Dacarel Lecibra Lecibral Lescodil Loxen NSC-757855 Nerdipina Nicant Nicapress Nicardal Nicardipine hcl
Status
Molecule Category	Salt-form
UNII	K5BC5011K3
EPA CompTox	DTXSID9046992
Parent Compound:	NICARDIPINE


InChI Key	AIKVCUNQWYTVTO-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1.Cl
InChI	InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

Mechanism of Action	Action	Reference
Voltage-gated L-type calcium channel blocker	BLOCKER	FDA PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	56.95-67.41

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	56.95-67.41


Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1F Organism : Homo sapiens O60840 ENSG00000102001












Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1D Organism : Homo sapiens Q01668 ENSG00000157388












Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1S Organism : Homo sapiens Q13698 ENSG00000081248











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1C Organism : Homo sapiens Q13936 ENSG00000151067

CONTENTS