EcoDrugPlus


Trade Names	ILEVRO NEVANAC
Synonyms	AHR-9434 AL-6515 Ilevro Nepafenac Nevanac
Status
Molecule Category	Free-form
ATC	S01BC10
UNII	0J9L7J6V8C
EPA CompTox	DTXSID0048638

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Bioactive chemicals

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	QEFAQIPZVLVERP-UHFFFAOYSA-N
Smiles	NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N
InChI	InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H14N2O2
Molecular Weight	254.29
AlogP	1.53
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	86.18
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	DailyMed

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Cross References

Resources	Reference
ChEBI	75922
ChEMBL	CHEMBL1021
DrugBank	DB06802
DrugCentral	1899
FDA SRS	0J9L7J6V8C
Human Metabolome Database	HMDB0015678
Guide to Pharmacology	7564
PharmGKB	PA165958407
PubChem	151075
SureChEMBL	SCHEMBL93835
ZINC	ZINC000005162311

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

NEPAFENAC

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References