NARATRIPTAN HYDROCHLORIDE

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Trade Names	AMERGE NARATRIPTAN
Synonyms	Amerge GR 85548A GR-85548A Naramig Naratriptan Naratriptan hcl Naratriptan hydrochloride
Status
Molecule Category	Salt-form
UNII	10X8X4P12Z
EPA CompTox	DTXSID6049064
Parent Compound:	NARATRIPTAN

Structure


InChI Key	AWEZYKMQFAUBTD-UHFFFAOYSA-N
Smiles	CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1.Cl
InChI	InChI=1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H26ClN3O2S
Molecular Weight	371.93
AlogP	2.07
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	65.2
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 1b (5-HT1b) receptor agonist	AGONIST	FDA

Target Conservation


Protein: Serotonin 1d (5-HT1d) receptor Description: 5-hydroxytryptamine receptor 1D Organism : Homo sapiens P28221 ENSG00000179546








Protein: Serotonin 1b (5-HT1b) receptor Description: 5-hydroxytryptamine receptor 1B Organism : Homo sapiens P28222 ENSG00000135312

Cross References

Resources	Reference
ChEBI	7479
ChEMBL	CHEMBL1200601
FDA SRS	10X8X4P12Z
Guide to Pharmacology	45
KEGG	C07792
PubChem	60875
SureChEMBL	SCHEMBL41527
ZINC	ZINC00004076

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025