MITOTANE


Trade Names	LYSODREN
Synonyms	CB 313 CB-313 Chloditan Chlodithane Lysodren Mitotan Mitotane NSC-38721 O,p'-ddd O,p'-ddd,o p'-tde O,p'-tde Opddd Opeprim
Status
Molecule Category	Free-form
ATC	L01XX23
UNII	78E4J5IB5J
EPA CompTox	DTXSID9020372


InChI Key	JWBOIMRXGHLCPP-UHFFFAOYSA-N
Smiles	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1
InChI	InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H

Property Name	Value
Molecular Formula	C14H10Cl4
Molecular Weight	320.05
AlogP	5.93
Number of Rotational Bond	3.0
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Cytochrome P450 11A1 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	98.27-107.64

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	98.27-107.64

Target Conservation

Query Gene : ENSG00000160882

Protein : Cytochrome P450 11B1

Description: Cytochrome P450 11B1, mitochondrial

Organism : Homo sapiens

Query Gene : ENSG00000160882

Protein : Cytochrome P450 11B1

Description: Cytochrome P450 11B1, mitochondrial

Organism : Homo sapiens

Query Gene : ENSG00000160882

Protein : Cytochrome P450 11B1

Description: Cytochrome P450 11B1, mitochondrial

Organism : Homo sapiens

Query Gene : ENSG00000160882

Target Name : Cytochrome P450 11B1

Organism : Homo sapiens

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	6954
ChEMBL	CHEMBL1670
DrugBank	DB00648
DrugCentral	1820
FDA SRS	78E4J5IB5J
Human Metabolome Database	HMDB0014786
Guide to Pharmacology	6957
PharmGKB	PA164746157
PubChem	4211
SureChEMBL	SCHEMBL4040

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MITOTANE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References


Protein: Cytochrome P450 11B1 Description: Cytochrome P450 11B1, mitochondrial Organism : Homo sapiens P15538 ENSG00000160882