MIDAZOLAM


Trade Names	NAYZILAM
Synonyms	Midazolam Midazolam civ Midazolam in 0.9% sodium chloride Nayzilam USL-261 USL261
Status
Molecule Category	Free-form
ATC	N05CD08
UNII	R60L0SM5BC
EPA CompTox	DTXSID5023320

Structure


InChI Key	DDLIGBOFAVUZHB-UHFFFAOYSA-N
Smiles	Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2
InChI	InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H13ClFN3
Molecular Weight	325.77
AlogP	4.32
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	1.0
Polar Surface Area	30.18
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
GABA-A receptor; anion channel positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	ISBN Wikipedia Wikipedia Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	-	99.46
Ion channel Ligand-gated ion channel GABA-A receptor	-	-	-	2	-
Membrane receptor	-	-	-	2	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	6.7-32.9
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	-	-	-	12

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	6.7-99.46

Target Conservation


Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit pi Organism : Homo sapiens O00591 ENSG00000094755










Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit delta Organism : Homo sapiens O14764 ENSG00000187730











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-1 Organism : Homo sapiens P14867 ENSG00000022355












Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-1 Organism : Homo sapiens P18505 ENSG00000163288








Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-2 Organism : Homo sapiens P18507 ENSG00000113327












Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-3 Organism : Homo sapiens P28472 ENSG00000166206












Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-5 Organism : Homo sapiens P31644 ENSG00000186297












Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-3 Organism : Homo sapiens P34903 ENSG00000011677











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-2 Organism : Homo sapiens P47869 ENSG00000151834











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-2 Organism : Homo sapiens P47870 ENSG00000145864











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-4 Organism : Homo sapiens P48169 ENSG00000109158










Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit epsilon Organism : Homo sapiens P78334 ENSG00000102287









Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-6 Organism : Homo sapiens Q16445 ENSG00000145863











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-1 Organism : Homo sapiens Q8N1C3 ENSG00000163285










Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-3 Organism : Homo sapiens Q99928 ENSG00000182256











Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit theta Organism : Homo sapiens Q9UN88 ENSG00000268089

Environmental Exposure

Environmental Exposure Map

Countries
Serbia
Slovenia

Cross References

Resources	Reference
ChEBI	6931
ChEMBL	CHEMBL655
DrugBank	DB00683
DrugCentral	1802
FDA SRS	R60L0SM5BC
Human Metabolome Database	HMDB0014821
Guide to Pharmacology	3342
KEGG	C07524
PDB	08J
PharmGKB	PA450496
PubChem	4192
SureChEMBL	SCHEMBL35061
ZINC	ZINC000095626706

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