METHIXENE HYDROCHLORIDE

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Search structure


Trade Names	TREST
Synonyms	Anhydrous metixene hydrochloride Methixene hcl Methixene hydrochloride Metixen Metixene hydrochloride Metixene hydrochloride anhydrous NSC-78194 SJ 1977 SJ-1977 Tremaril Tremarit Tremonil Trest
Status
Molecule Category	Salt-form
UNII	84L8XK6N1G

Structure


InChI Key	RAOHHYUBMJLHNC-UHFFFAOYSA-N
Smiles	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1.Cl.O
InChI	InChI=1S/C20H23NS.ClH.H2O/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H26ClNOS
Molecular Weight	363.95
AlogP	5.02
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	3.24
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Muscarinic acetylcholine receptor M1 antagonist	ANTAGONIST	ISBN PubMed

Target Conservation


Protein: Muscarinic acetylcholine receptor M1 Description: Muscarinic acetylcholine receptor M1 Organism : Homo sapiens P11229 ENSG00000168539










Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246

Cross References

Resources	Reference
ChEBI	51025
ChEMBL	CHEMBL1200426
FDA SRS	84L8XK6N1G
KEGG	D08209
PubChem	71177
SureChEMBL	SCHEMBL121381
ZINC	ZINC01713960

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025