|
Inhibition of human recombinant carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase I (CA1)
|
None
|
780.0
nM
|
|
|
Compound was evaluated for inhibition against human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes
|
None
|
21.0
nM
|
|
|
In vitro inhibition of human Carbonic Anhydrase II
|
None
|
21.0
nM
|
|
|
Inhibitory activity of compound against human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II was determined
|
None
|
14.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase II
|
None
|
21.0
nM
|
|
|
Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C
|
None
|
14.0
nM
|
|
|
In vitro inhibitory activity against human carbonic anhydrase II (hCAII)
|
None
|
14.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II)
|
None
|
14.0
nM
|
|
|
Inhibitory activity against Human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase II (hCA II)
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.
|
None
|
14.0
nM
|
|
|
Inhibitory effect on human Carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)
|
None
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
|
None
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II.
|
None
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase II (CA2)
|
None
|
14.0
nM
|
|
|
Inhibitory activity of compound against bovine carbonic anhydrase IV
|
None
|
36.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV was determined
|
None
|
36.0
nM
|
|
|
Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C
|
None
|
240.0
nM
|
|
|
In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)
|
None
|
240.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes
|
None
|
240.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV
|
None
|
240.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)
|
None
|
36.0
nM
|
|
|
Inhibitory effect on bovine Carbonic anhydrase IV
|
Bos taurus
|
240.0
nM
|
|
|
Compound was evaluated for inhibition against bovine carbonic anhydrase IV
|
None
|
36.0
nM
|
|
|
Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes
|
None
|
36.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.
|
None
|
36.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes
|
None
|
240.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung
|
Bos taurus
|
145.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes
|
None
|
36.0
nM
|
|
|
Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes
|
None
|
240.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV)
|
None
|
36.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX was determined
|
None
|
27.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of human CA IX (Carbonic anhydrase IX)
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.
|
None
|
27.0
nM
|
|
|
Compound was evaluated for inhibition against human carbonic anhydrase IX
|
None
|
27.0
nM
|
|
|
Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
|
None
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX.
|
None
|
27.0
nM
|
|
|
Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.
|
None
|
27.0
nM
|
|
|
Inhibition of murine mitochondrial isozyme Carbonic anhydrase V at 20 degrees C
|
None
|
63.0
nM
|
|
|
Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
|
None
|
19.0
nM
|
|
|
In vitro inhibition of carbonic anhydrase was determined using enzyme prepared from mouse erythrocytes
|
None
|
4e-08
%
|
|
|
Evaluated for its activity against carbonic anhydrase (CA) in anesthetized rabbits
|
Oryctolagus cuniculus
|
20.0
nM
|
|
|
Inhibitory activity of compound against human carbonic anhydrase I
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I was determined
|
None
|
50.0
nM
|
|
|
Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
In vitro inhibitory activity against human carbonic anhydrase I (hCAI)
|
None
|
780.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of human CA I (Carbonic anhydrase I)
|
None
|
50.0
nM
|
|
|
Inhibitory activity against Human carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase I (CA1)
|
None
|
780.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase I (hCA I)
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.
|
None
|
780.0
nM
|
|
|
Inhibitory effect on human carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Compound was evaluated for inhibition against human carbonic anhydrase I
|
None
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition constant determined against human cloned carbonic anhydrase I
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I (hCA I)
|
None
|
100.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I.
|
None
|
780.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase I
|
None
|
780.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase II
|
None
|
14.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase IV
|
None
|
240.0
nM
|
|
|
Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase I
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Ki value against human carbonic anhydrase I
|
Homo sapiens
|
50.0
nM
|
|
|
Ki value against human carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Ki value against human carbonic anhydrase VII
|
Homo sapiens
|
2.1
nM
|
|
|
Ratio against Carbonic anhydrase II to Carbonic anhydrase IX
|
Homo sapiens
|
0.52
Ratio
|
|
|
Ki value against human carbonic anhydrase I (hCA I)
|
Homo sapiens
|
50.0
nM
|
|
|
Ki value against human carbonic anhydrase II (hCA II)
|
Homo sapiens
|
14.0
nM
|
|
|
Ki value against murine carbonic anhydrase XIII
|
Mus musculus
|
19.0
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Ki value against human carbonic anhydrase XII (hCA XII)
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase I
|
Homo sapiens
|
280.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase XI
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I (hCAI)
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCAII)
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)
|
Bos taurus
|
36.0
nM
|
|
|
Inhibitory activity against cytosolic human carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory activity against cytosolic human carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase I
|
Homo sapiens
|
50.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21
|
Homo sapiens
|
50.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
Homo sapiens
|
14.0
nM
|
|
|
Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method
|
Homo sapiens
|
15.4
nM
|
|
|
Inhibitory activity against human carbonic anhydrase I at 0.09 uM
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
170.0
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
140.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
3.4
nM
|
|
|
Mean inhibitory constant towards human carbonic anhydrase V determined by spectrophotometric dansylamide binding assay
|
Homo sapiens
|
2.5
nM
|
|
|
Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against human recombinant cytosolic CA2
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VA
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VB
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibitory activity against cloned human CA1
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against cloned human CA2
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibitory activity against CA4 isolated from bovine lung microsomes
|
Bos taurus
|
36.0
nM
|
|
|
Inhibitory activity against cloned human CA9
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against cloned human CA12
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
|
Helicobacter pylori
|
225.0
nM
|
|
|
Inhibition of human recombinant CA1
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant CA
|
Helicobacter pylori
|
171.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration method
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned CA9 catalytic domain by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned CA1 by stopped-flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA2 by stopped-flow CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned CA5A by stopped-flow CO2 hydration method
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human cloned CA5B by stopped-flow CO2 hydration method
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human cloned CA7 by stopped-flow CO2 hydration method
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of murine CA13 by stopped-flow CO2 hydration method
|
Mus musculus
|
19.0
nM
|
|
|
Inhibition of human cloned CA14 by stopped-flow CO2 hydration method
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of full length human recombinant CA VI
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant CA IX
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant isozyme CA1 by CO2 hydration method
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human recombinant isozyme CA2 by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant CA12 by CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human recombinant CA14 by CO2 hydration assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned catalytic domain CA9 by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase 3
|
Homo sapiens
|
1.1
nM
|
|
|
Inhibition of human carbonic anhydrase 5A
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5B
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human carbonic anhydrase 6
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human carbonic anhydrase 7
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human carbonic anhydrase 9
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of mouse carbonic anhydrase 13
|
Mus musculus
|
19.0
nM
|
|
|
Inhibition of human carbonic anhydrase 14
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human CA9 catalytic domain by CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay
|
Mus musculus
|
19.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
781.0
nM
|
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis H37Rv
|
562.0
nM
|
|
|
Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method
|
Mus musculus
|
19.0
nM
|
|
|
Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
|
Saccharomyces cerevisiae
|
119.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
|
Mus musculus
|
65.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis H37Rv recombinant beta-carbonic anhydrase 1 expressed in Escherichia coli BL21 by stopped flow CO2 hydration method
|
Mycobacterium tuberculosis H37Rv
|
781.0
nM
|
|
|
Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay
|
Mus musculus
|
19.0
nM
|
|
|
Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of Caenorhabditis elegans CAH-4b by stopped flow CO2 hydration assay
|
Caenorhabditis elegans
|
42.0
nM
|
|
|
Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay
|
Candida albicans
|
484.0
nM
|
|
|
Inhibition of Cryptococcus neoformans recombinant Can2 by stopped-flow CO2 hydration assay
|
Cryptococcus neoformans
|
63.0
nM
|
|
|
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
14.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
|
Stylophora pistillata
|
21.2
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
660.0
nM
|
|
|
Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
781.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
562.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
21.2
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
132.0
nM
|
|
|
Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3
|
Brucella suis
|
642.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3
|
Brucella suis
|
54.0
nM
|
|
|
Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
65.0
nM
|
|
|
Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
62.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5
|
Leptonychotes weddellii
|
61.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
19.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 1 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
134.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 2 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
68.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Astrosclera willeyana
|
326.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Cryptococcus neoformans
|
63.0
nM
|
|
|
Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Candida albicans
|
484.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Vibrio cholerae
|
3.6
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay
|
Trypanosoma cruzi
|
74.9
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
0.25
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
4.8
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
67.6
nM
|
|
|
Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Candida glabrata
|
118.0
nM
|
|
|
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Sulfurihydrogenibium yellowstonense
|
8.2
nM
|
|
|
Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Helicobacter pylori
|
225.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
2.1
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of recombinant Leishmania donovani chagasi beta-carbonic anhydrase expressed in baculovirus infected insect Sf9 cells incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leishmania donovani chagasi
|
87.1
nM
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
101.26
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
93.09
%
|
|
|
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Thalassiosira weissflogii
|
170.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
343.0
nM
|
|
|
Inhibition of Leishmania donovani chagasi recombinant beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Leishmania chagasi
|
87.1
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-CA CAM by stopped flow CO2 hydration assay
|
Leishmania donovani chagasi
|
140.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
343.0
nM
|
|
|
Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-1 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
201.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
88.5
nM
|
|
|
Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
176.0
nM
|
|
|
Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Helicobacter pylori Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Helicobacter pylori
|
176.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
393.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
343.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay
|
Plasmodium falciparum
|
198.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Methanosarcina thermophila
|
140.0
nM
|
|
|
Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Porphyromonas gingivalis
|
343.0
nM
|
|
|
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Nostoc commune
|
191.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Anopheles gambiae
|
184.0
nM
|
|
|
Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of recombinant Streptococcus mutans UA159 beta-carbonic anhydrase expressed in Escherichia coli Arctic cells preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Streptococcus mutans UA159
|
445.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay
|
Nostoc commune
|
191.0
nM
|
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase by CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
94.7
nM
|
|
|
Inhibition of Methanosarcina thermophila recombinant gamma carbonic anhydrase by stopped flow CO2 hydrase assay method
|
Methanosarcina thermophila
|
140.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of weddell seal alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leptonychotes weddellii
|
61.0
nM
|
|
|
Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Chionodraco hamatus
|
65.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Sulfurihydrogenibium yellowstonense
|
8.2
nM
|
|
|
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Thiomicrospira crunogena XCL-2
|
26.5
nM
|
|
|
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
3.6
nM
|
|
|
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
343.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Nostoc commune
|
191.0
nM
|
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
94.7
nM
|
|
|
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Colwellia psychrerythraea
|
594.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Enterobacter sp.
|
137.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
494.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Vibrio cholerae
|
494.0
nM
|
|
|
Inhibition of Burkholderia pseudomallei beta-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Burkholderia pseudomallei
|
186.0
nM
|
|
|
Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
780.0
nM
|
|
|
Inhibition of recombinant human full-length carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
34.0
nM
|
|
|
Inhibition of full length human CA 1
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of full length human CA 2
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of human CA 9 catalytic domain
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human CA 12 catalytic domain
|
Homo sapiens
|
3.4
nM
|
|
|
Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
14.0
nM
|
|
|
Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase (181 to 538 residues) expressed in Escherichia coli artic express (DE3) preincubated for 15 mins by stop flow CO2 hydrase assay
|
Plasmodium falciparum
|
655.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
18.3
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
9.91
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.14
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.14
%
|
|
