MESORIDAZINE BESYLATE

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Search structure


Trade Names	SERENTIL
Synonyms	Mesoridazine benzenesulfonate Mesoridazine besilate Mesoridazine besylate NSC-760073 Serentil
Status
Molecule Category	Salt-form
UNII	T4G2I958J2

Structure


InChI Key	CRJHBCPQHRVYBS-UHFFFAOYSA-N
Smiles	CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21.O=S(=O)(O)c1ccccc1
InChI	InChI=1S/C21H26N2OS2.C6H6O3S/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23;7-10(8,9)6-4-2-1-3-5-6/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1-5H,(H,7,8,9)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H32N2O4S3
Molecular Weight	544.76
AlogP	4.9
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	4.0
Polar Surface Area	23.55
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed PubMed Wikipedia

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468

Cross References

Resources	Reference
ChEBI	6781
ChEMBL	CHEMBL1201052
FDA SRS	T4G2I958J2
KEGG	C07143
PubChem	36207
SureChEMBL	SCHEMBL41229
ZINC	ZINC03831042

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025