MEGESTROL ACETATE

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Trade Names
Synonyms
Status
Molecule Category Free-form
UNII TJ2M0FR8ES
EPA CompTox DTXSID9040683
Parent Compound:

Structure

InChI Key RQZAXGRLVPAYTJ-GQFGMJRRSA-N
Smiles CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChI
InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H32O4
Molecular Weight 384.52
AlogP 4.58
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 2.0
Polar Surface Area 60.44
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 28.0

Pharmacology

Mechanism of Action Action Reference
Progesterone receptor agonist AGONIST PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 50.69-93.03
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 50.69-93.03

Target Conservation

Protein: Progesterone receptor
Description: Progesterone receptor
Organism : Homo sapiens
P06401 ENSG00000082175

Cross References

Resources Reference
ChEBI 6723
ChEMBL CHEMBL1201139
DrugBank DB00351
DrugCentral 1667
FDA SRS TJ2M0FR8ES
KEGG C08151
PubChem 11683
SureChEMBL SCHEMBL745
ZINC ZINC000004097467
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