MECLOFENAMATE SODIUM

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 94NJ818U2W
EPA CompTox DTXSID8045567
Parent Compound:

Structure

InChI Key QHJLLDJTVQAFAN-UHFFFAOYSA-M
Smiles Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl.O.[Na+]
InChI
InChI=1S/C14H11Cl2NO2.Na.H2O/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;1H2/q;+1;/p-1

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H12Cl2NNaO3
Molecular Weight 336.15
AlogP 4.74
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 49.33
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Mechanism of Action Action Reference
Arachidonate 5-lipoxygenase inhibitor INHIBITOR PubMed DailyMed

Target Conservation

Protein: Arachidonate 5-lipoxygenase
Description: Polyunsaturated fatty acid 5-lipoxygenase
Organism : Homo sapiens
P09917 ENSG00000012779
Protein: Cyclooxygenase
Description: Prostaglandin G/H synthase 1
Organism : Homo sapiens
P23219 ENSG00000095303
Protein: Cyclooxygenase
Description: Prostaglandin G/H synthase 2
Organism : Homo sapiens
P35354 ENSG00000073756

Cross References

Resources Reference
ChEBI 76232
ChEMBL CHEMBL1562610
FDA SRS 94NJ818U2W
KEGG C02996
PubChem 23663959
SureChEMBL SCHEMBL3504
ZINC ZINC00001655
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