LOXAPINE HYDROCHLORIDE

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Search structure


Trade Names	LOXITANE C LOXITANE IM
Synonyms	Loxapine hcl Loxapine hydrochloride Loxitane c Loxitane im
Status
Molecule Category	Salt-form
UNII	376MYL4MAL
EPA CompTox	DTXSID70203304
Parent Compound:

Structure


InChI Key	JSXBVMKACNEMKY-UHFFFAOYSA-N
Smiles	CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1.Cl
InChI	InChI=1S/C18H18ClN3O.ClH/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;/h2-7,12H,8-11H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H19Cl2N3O
Molecular Weight	364.28
AlogP	3.77
Hydrogen Bond Acceptor	4.0
Polar Surface Area	28.07
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
D2-like dopamine receptor antagonist	ANTAGONIST	FDA

Target Conservation


Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246

Cross References

Resources	Reference
ChEMBL	CHEMBL1201060
FDA SRS	376MYL4MAL
PubChem	71400
SureChEMBL	SCHEMBL41625

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025