Trade Names | |
Synonyms | |
Status | |
Molecule Category | Free-form |
ATC | N05BA06 |
UNII | O26FZP769L |
EPA CompTox | DTXSID7023225 |
InChI Key | DIWRORZWFLOCLC-UHFFFAOYSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C15H10Cl2N2O2 | |
Molecular Weight | 321.16 | |
AlogP | 3.1 | |
Hydrogen Bond Acceptor | 3.0 | |
Hydrogen Bond Donor | 2.0 | |
Number of Rotational Bond | 1.0 | |
Polar Surface Area | 61.69 | |
Molecular species | NEUTRAL | |
Aromatic Rings | 2.0 | |
Heavy Atoms | 21.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | PubMed PubMed Wikipedia |
Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit pi Organism : Homo sapiens O00591 ENSG00000094755 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit delta Organism : Homo sapiens O14764 ENSG00000187730 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-1 Organism : Homo sapiens P14867 ENSG00000022355 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-1 Organism : Homo sapiens P18505 ENSG00000163288 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-2 Organism : Homo sapiens P18507 ENSG00000113327 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-3 Organism : Homo sapiens P28472 ENSG00000166206 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-5 Organism : Homo sapiens P31644 ENSG00000186297 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-3 Organism : Homo sapiens P34903 ENSG00000011677 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-2 Organism : Homo sapiens P47869 ENSG00000151834 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit beta-2 Organism : Homo sapiens P47870 ENSG00000145864 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-4 Organism : Homo sapiens P48169 ENSG00000109158 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit epsilon Organism : Homo sapiens P78334 ENSG00000102287 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit alpha-6 Organism : Homo sapiens Q16445 ENSG00000145863 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-1 Organism : Homo sapiens Q8N1C3 ENSG00000163285 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit gamma-3 Organism : Homo sapiens Q99928 ENSG00000182256 |
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Protein: GABA-A receptor; anion channel Description: Gamma-aminobutyric acid receptor subunit theta Organism : Homo sapiens Q9UN88 ENSG00000268089 |
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Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Auxiliary transport protein
Fatty acid binding protein family
|
- | - | - | 12900 | - |
Resources | Reference | |
---|---|---|
ChEBI | 6539 | |
ChEMBL | CHEMBL580 | |
DrugBank | DB00186 | |
DrugCentral | 1606 | |
FDA SRS | O26FZP769L | |
Human Metabolome Database | HMDB0014332 | |
Guide to Pharmacology | 5884 | |
KEGG | D00365 | |
PharmGKB | PA450267 | |
PubChem | 3958 | |
SureChEMBL | SCHEMBL26961 | |
ZINC | ZINC00896595 |