LOMEFLOXACIN HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 9VC7S3ZXXB
EPA CompTox DTXSID2045527

Structure

InChI Key KXEBLAPZMOQCKO-UHFFFAOYSA-N
Smiles CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21.Cl
InChI
InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H20ClF2N3O3
Molecular Weight 387.81
AlogP 1.8
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 74.57
Molecular species ZWITTERION
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Mechanism of Action Action Reference
Bacterial DNA gyrase inhibitor INHIBITOR DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 75.12-101.03
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 75.12-101.03

Cross References

Resources Reference
ChEBI 6518
ChEMBL CHEMBL1728
FDA SRS 9VC7S3ZXXB
KEGG C08053
PubChem 68624
SureChEMBL SCHEMBL42051
ZINC ZINC03873157
CONTENTS