LIDOCAINE HYDROCHLORIDE


Trade Names	AKTEN ALPHACAINE HYDROCHLORIDE ANESTACON GLYDO LARYNG-O-JET KIT LARYNGOTRACHEAL ANESTHESIA KIT LIDOCAINE HYDROCHLORIDE LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.8% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 5% AND DEXTROSE 7.5% LIDOCAINE HYDROCHLORIDE IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE VISCOUS LIDOCAINE VISCOUS LIDOCATON LIDOPEN LTA II KIT PEDIATRIC LTA KIT XYLOCAINE XYLOCAINE 1.5% W/ DEXTROSE 7.5% XYLOCAINE 4% PRESERVATIVE FREE XYLOCAINE 5% W/ GLUCOSE 7.5% XYLOCAINE DENTAL XYLOCAINE PRESERVATIVE FREE XYLOCAINE VISCOUS ZINGO
Synonyms	Akten Alphacaine hydrochloride Anestacon Anodesyn Bismodyne Bradosol plus Calgel Co-phenylcaine fte Denela Dequaspray Emla Germoloids Germoloids complete Glydo Hemocane Iglu Instillagel Laryng-o-jet kit Laryngojet Laryngotracheal anesthesia kit Lido hcl Lidocaine hcl Lidocaine hydrochloride Lidocaine hydrochloride monohydrate Lidocaine hydrochloride preservative free Lidocaine hydrochloride usp Lidocaine hydrochloride viscous Lidocaine viscous Lidocaini hydrochloridum Lidocaton Lidopen Lignocaine (as hydrochloride) Lignocaine hydrochloride Lignokent Lignospan special Lignostab Lignostab a 100 Lignostab n Lignostab-a Lta ii kit Medijel NSC-757420 Oragard Pediatric lta kit Preparation h Rexocaine Versatis Xylocaine Xylocaine dental Xylocaine hydrochloride Xylocaine preservative free Xylocaine viscous Xylotox e80 Zingo
Status
Molecule Category	Salt-form
UNII	V13007Z41A
EPA CompTox	DTXSID80209953
Parent Compound:	LIDOCAINE


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	YECIFGHRMFEPJK-UHFFFAOYSA-N
Smiles	CCN(CC)CC(=O)Nc1c(C)cccc1C.Cl.O
InChI	InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H25ClN2O2
Molecular Weight	288.82
AlogP	2.58
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	32.34
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Bioactivity

Mechanism of Action	Action	Reference
Sodium channel alpha subunit blocker	BLOCKER	PubMed PubMed


Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314











Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873








Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253









Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876











Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313

Cross References

Resources	Reference
ChEBI	60791
ChEMBL	CHEMBL1200409
FDA SRS	V13007Z41A
Guide to Pharmacology	2623
KEGG	C07073
PDB	LQZ
PubChem	22483
SureChEMBL	SCHEMBL29128
ZINC	ZINC00020237

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