IVABRADINE HYDROCHLORIDE

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Search structure


Trade Names	CORLANOR
Synonyms	AMG 998 AMG-998 Corlanor Corlentor Ivabradine Ivabradine hcl Ivabradine hydrochloride Procoralan S 16257 S-16257-2
Status
Molecule Category	Salt-form
UNII	TP19837BZK
EPA CompTox	DTXSID2046913
Parent Compound:	IVABRADINE

Structure


InChI Key	HLUKNZUABFFNQS-ZMBIFBSDSA-N
Smiles	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2.Cl
InChI	InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H37ClN2O5
Molecular Weight	505.06
AlogP	3.31
Hydrogen Bond Acceptor	6.0
Number of Rotational Bond	10.0
Polar Surface Area	60.47
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	34.0

Pharmacology

Mechanism of Action	Action	Reference
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker	BLOCKER	PubMed DailyMed

Target Conservation


Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Description: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Organism : Homo sapiens Q9Y3Q4 ENSG00000138622

Cross References

Resources	Reference
ChEBI	85969
ChEMBL	CHEMBL2145077
FDA SRS	TP19837BZK
PubChem	3045381
SureChEMBL	SCHEMBL23470

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025