ISRADIPINE


Trade Names	DYNACIRC DYNACIRC CR ISRADIPINE
Synonyms	Dynacirc Dynacirc cr Isradipine Isrodipine NSC-759892 PN 200-110 PN-200-110 Prescal
Status
Molecule Category	Free-form
ATC	C08CA03
UNII	YO1UK1S598
EPA CompTox	DTXSID4023179


InChI Key	HMJIYCCIJYRONP-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12
InChI	InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

Mechanism of Action	Action	Reference
Voltage-gated L-type calcium channel blocker	BLOCKER	Wikipedia Wikipedia Wikipedia Wikipedia DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated calcium channel	-	2.2-221	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	7.7-47.5

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	2.2	-	-	7.7-47.5
Oryctolagus cuniculus	-	107	-	-	-
Rattus norvegicus	-	221	-	-	-


Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1F Organism : Homo sapiens O60840 ENSG00000102001












Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1D Organism : Homo sapiens Q01668 ENSG00000157388












Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1S Organism : Homo sapiens Q13698 ENSG00000081248











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1C Organism : Homo sapiens Q13936 ENSG00000151067

CONTENTS