IMATINIB MESYLATE


Trade Names	GLEEVEC IMATINIB MESYLATE
Synonyms	Gleevec Glivec Imatinib (as mesilate) Imatinib accord Imatinib medac Imatinib mesilate Imatinib mesylate Imatinib methane sulfonate Imatinib methanesulfonate NSC-716051 QTI-571 QTI571 Qti571 STI 571 STI-571
Status
Molecule Category	Salt-form
UNII	8A1O1M485B
EPA CompTox	DTXSID9040502
Parent Compound:	IMATINIB


InChI Key	YLMAHDNUQAMNNX-UHFFFAOYSA-N
Smiles	CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
InChI	InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

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Mechanism of Action	Action	Reference
Bcr/Abl fusion protein	INHIBITOR	FDA
Platelet-derived growth factor receptor beta inhibitor	INHIBITOR	DailyMed Wikipedia
Stem cell growth factor receptor inhibitor	INHIBITOR	DailyMed Wikipedia
Tyrosine-protein kinase ABL inhibitor	INHIBITOR	DailyMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C8	-	-	-	-	45-45
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	-	80-80
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase BCR family	90	-	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family	90	430	-	-	95-99
Other cytosolic protein	90	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	90-600	152.2-830	-	-	45-99
Mus musculus	-	-	-	-	20-40


Protein: Bcr/Abl fusion protein Description: Tyrosine-protein kinase ABL1 Organism : Homo sapiens P00519 ENSG00000097007












Protein: Tyrosine-protein kinase ABL Description: Tyrosine-protein kinase ABL1 Organism : Homo sapiens P00519 ENSG00000097007












Protein: Platelet-derived growth factor receptor beta Description: Platelet-derived growth factor receptor beta Organism : Homo sapiens P09619 ENSG00000113721











Protein: Stem cell growth factor receptor Description: Mast/stem cell growth factor receptor Kit Organism : Homo sapiens P10721 ENSG00000157404












Protein: Bcr/Abl fusion protein Description: Breakpoint cluster region protein Organism : Homo sapiens P11274 ENSG00000186716

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