HYDROXYZINE HYDROCHLORIDE

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Search structure


Trade Names	ATARAX HYDROXYZINE HYDROXYZINE HYDROCHLORIDE ORGATRAX VISTARIL
Synonyms	Atarax Hydroxizine chloride Hydroxyzine Hydroxyzine dihydrochloride Hydroxyzine hydrochloride Orgatrax Ucerax Vistaril
Status
Molecule Category	Salt-form
UNII	GF8H55RPZ9
EPA CompTox	DTXSID2040737
Parent Compound:	HYDROXYZINE

Structure


InChI Key	ANOMHKZSQFYSBR-UHFFFAOYSA-N
Smiles	Cl.Cl.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChI	InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H29Cl3N2O2
Molecular Weight	447.83
AlogP	3.06
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	35.94
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	ISBN PubMed

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	5819
ChEMBL	CHEMBL3186993
FDA SRS	GF8H55RPZ9
Guide to Pharmacology	7199
KEGG	C07045
PubChem	91513
SureChEMBL	SCHEMBL41449
ZINC	ZINC19364224

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025