HYDROXYUREA

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Search structure


Trade Names	DROXIA HYDREA HYDROXYUREA SIKLOS
Synonyms	Droxia Hydrea Hydroxycarbamide Hydroxyurea NSC-32065 SQ 1089 SQ-1089 Siklos
Status
Molecule Category	Free-form
UNII	X6Q56QN5QC
EPA CompTox	DTXSID6025438

Structure


InChI Key	VSNHCAURESNICA-UHFFFAOYSA-N
Smiles	NC(=O)NO
InChI	InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	CH4N2O2
Molecular Weight	76.05
AlogP	-0.96
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	3.0
Polar Surface Area	75.35
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	5.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action	Action	Reference
Ribonucleoside-diphosphate reductase RR1 inhibitor	INHIBITOR	PubMed DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	87.55-113.37

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	87.55-113.37
Homo sapiens	-	-	-	-	34.3-90
Leishmania mexicana	-	-	-	-	44-100

Cross References

Resources	Reference
ChEBI	44423
ChEMBL	CHEMBL467
DrugBank	DB01005
DrugCentral	1399
FDA SRS	X6Q56QN5QC
Human Metabolome Database	HMDB0015140
Guide to Pharmacology	6822
KEGG	C07044
PDB	NHY
PharmGKB	PA449942
PubChem	3657
SureChEMBL	SCHEMBL4004
ZINC	ZINC000008034120

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025