EcoDrugPlus


Trade Names	DIUCARDIN HYDROFLUMETHIAZIDE SALURON
Synonyms	Diucardin Hydrenox Hydroflumethiazide NSC-44627 Saluron
Status
Molecule Category	Free-form
ATC	C03AA02
UNII	501CFL162R
EPA CompTox	DTXSID3023132


InChI Key	DMDGGSIALPNSEE-UHFFFAOYSA-N
Smiles	NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O
InChI	InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

Property Name	Value
Molecular Formula	C8H8F3N3O4S2
Molecular Weight	331.3
AlogP	0.01
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	1.0
Polar Surface Area	118.36
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	20.0

Mechanism of Action	Action	Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor	INHIBITOR	DOI

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	82.22-85.97

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	82.22-85.97

Resources	Reference
ChEBI	5784
ChEMBL	CHEMBL1763
DrugBank	DB00774
DrugCentral	1392
FDA SRS	501CFL162R
Human Metabolome Database	HMDB0014912
Guide to Pharmacology	7197
KEGG	C07763
PDB	HFZ
PharmGKB	PA164752557
PubChem	3647
SureChEMBL	SCHEMBL27028
ZINC	ZINC000000897225

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

HYDROFLUMETHIAZIDE

Structure

Physicochemical Descriptors

Pharmacology

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