GUAIFENESIN

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Search structure


Trade Names	GUAIFENESIN MUCINEX
Synonyms	Amonidron CVT-2534 Famel Franolyn chesty Gecolate Glycerol Guaiacolate Glyceryl guaiacolate Guaiacol glyceryl ether Guaifenesin Guaifensin Guaiphenesin Humabid Hustosil Liqufruta Methphenoxydiol
Status
Molecule Category	Free-form
ATC	R05CA03
UNII	495W7451VQ
EPA CompTox	DTXSID5023114

Structure


InChI Key	HSRJKNPTNIJEKV-UHFFFAOYSA-N
Smiles	COc1ccccc1OCC(O)CO
InChI	InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H14O4
Molecular Weight	198.22
AlogP	0.43
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	58.92
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	14.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	93.55-97.97

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	93.55-97.97
Homo sapiens	-	-	-	-	34

Cross References

Resources	Reference
ChEBI	5551
ChEMBL	CHEMBL980
DrugBank	DB00874
DrugCentral	1336
FDA SRS	495W7451VQ
Human Metabolome Database	HMDB0004998
Guide to Pharmacology	7617
PharmGKB	PA449818
PubChem	3516
SureChEMBL	SCHEMBL4321

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025