FLUTICASONE PROPIONATE

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Search structure


Trade Names	ARMONAIR RESPICLICK CUTIVATE FLONASE FLONASE ALLERGY RELIEF FLOVENT FLOVENT DISKUS 100 FLOVENT DISKUS 250 FLOVENT DISKUS 50 FLOVENT HFA FLUTICASONE PROPIONATE XHANCE
Synonyms	Aerivio spiromax Airflusal forspiro Armonair digihaler Armonair respiclick CCI 18781 CCI-18781 Cutivate FLOVENT Flixonase Flixotide Flonase Flonase allergy relief Flovent Flovent diskus 100 Flovent diskus 250
Status
Molecule Category	Free-form
UNII	O2GMZ0LF5W
Parent Compound:

Structure


InChI Key	WMWTYOKRWGGJOA-CENSZEJFSA-N
Smiles	CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
InChI	InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H31F3O5S
Molecular Weight	500.58
AlogP	4.43
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	80.67
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	34.0

Pharmacology

Mechanism of Action	Action	Reference
Glucocorticoid receptor agonist	AGONIST	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 1	0.7-1.09	0.04-5	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 2	-	149	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 3	-	21	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	0.7-1.09	0.04-149	-	-	-
Rattus norvegicus	0.76	0.14	-	-	0-116

Target Conservation


Protein: Glucocorticoid receptor Description: Glucocorticoid receptor Organism : Homo sapiens P04150 ENSG00000113580

Cross References

Resources	Reference
ChEBI	31441
ChEMBL	CHEMBL1473
DrugBank	DB00588
DrugCentral	1225
FDA SRS	O2GMZ0LF5W
Human Metabolome Database	HMDB0005036
Guide to Pharmacology	7080
PharmGKB	PA449686
PubChem	444036
SureChEMBL	SCHEMBL4068
ZINC	ZINC000003920027

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025