FLUTICASONE FUROATE

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Search structure


Trade Names	ARNUITY ELLIPTA FLONASE SENSIMIST ALLERGY RELIEF
Synonyms	Allermist Arnuity ellipta Avamys Ennhale Flonase sensimist allergy relief Fluticasone furoate Furamist GSK 685 698 GSK-685968 GSK685968 GW-685698X GW685698X Relvar ellipta Trelegy ellipta Veramyst
Status
Molecule Category	Free-form
ATC	R01AD12 R03BA09
UNII	JS86977WNV
EPA CompTox	DTXSID60228586
Parent Compound:

Structure


InChI Key	XTULMSXFIHGYFS-VLSRWLAYSA-N
Smiles	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF
InChI	InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H29F3O6S
Molecular Weight	538.58
AlogP	4.93
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	93.81
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Glucocorticoid receptor agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 1	0.4-0.49	0.03981-0.8	-	0.51	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 2	-	166	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 3	-	21	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	90
Homo sapiens	0.4-0.49	0.03981-166	-	0.51	-
Mus musculus	-	0.1	-	-	-

Target Conservation


Protein: Glucocorticoid receptor Description: Glucocorticoid receptor Organism : Homo sapiens P04150 ENSG00000113580

Cross References

Resources	Reference
ChEBI	74899
ChEMBL	CHEMBL1676
DrugBank	DB08906
DrugCentral	4554
FDA SRS	JS86977WNV
Guide to Pharmacology	10892
PDB	GW6
PubChem	9854489
SureChEMBL	SCHEMBL140504
ZINC	ZINC000003992105

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025