|
Antifungal activity expressed as inhibitory concentration against Candida albicans CY1002 in YNBPB medium
|
Candida albicans
|
720.0
nM
|
|
|
Antifungal activity expressed as inhibitory concentration against Candida albicans CY1002 in calf serum
|
Candida albicans
|
500.0
nM
|
|
|
Antifungal activity expressed as inhibitory concentration against Candida albicans in calf serum
|
Candida albicans
|
500.0
nM
|
|
|
Antifungal activity against Candida albicans CY1002
|
Candida albicans
|
720.0
nM
|
|
|
In vitro antifungal activity against Candida albicans CY 1002
|
Candida albicans
|
1.2
ug.mL-1
|
|
|
In vitro antifungal activity against Candida albicans (CY1002) in 80% calf serum
|
Candida albicans
|
500.0
nM
|
|
|
In vitro antifungal activity against Candida albicans (CY1002) in YNBPB medium
|
Candida albicans
|
720.0
nM
|
|
|
In vitro antifungal activity against Aspergillus fumigatus CF 1003
|
candida fumigatus
|
50.0
ug.mL-1
|
|
|
In vitro antifungal activity against Candida neoformans CY 1057
|
candida neoformans
|
3.4
ug.mL-1
|
|
|
In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005)
|
Candida albicans
|
0.042
ug.mL-1
|
|
|
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 (experiment 1)
|
Candida albicans
|
0.042
ug.mL-1
|
|
|
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 (experiment 2)
|
Candida albicans
|
0.039
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028
|
Candida albicans
|
0.22
ug.mL-1
|
|
|
Antifungal activity against fluconazole-susceptible Candida albicans
|
Candida albicans
|
0.24
ug.mL-1
|
|
|
Antifungal activity against fluconazole-resistant Candida albicans
|
Candida albicans
|
118.0
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans ATCC 90113
|
Cryptococcus neoformans
|
5.65
ug.mL-1
|
|
|
Antifungal activity against Aspergillus fumigatus ATCC 90906
|
Aspergillus fumigatus
|
200.0
ug.mL-1
|
|
|
Cytotoxicity against Vero cells by neutral red method
|
Chlorocebus sabaeus
|
10.0
ug.mL-1
|
|
|
Cytotoxicity against LLC-PK1 cells by neutral red method
|
Sus scrofa
|
10.0
ug.mL-1
|
|
|
Antifungal activity against Candida albicans by broth microdilution technique
|
Candida albicans
|
0.13
ug.mL-1
|
|
|
Antifungal activity against Candida parapsilosis ATCC 22019 by broth microdilution technique
|
Candida parapsilosis
|
0.21
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans by broth microdilution technique
|
Cryptococcus neoformans
|
0.46
ug.mL-1
|
|
|
Antifungal activity against Aspergillus fumigatus by broth microdilution technique
|
Aspergillus fumigatus
|
1.06
ug.mL-1
|
|
|
Antifungal activity against Sporothrix schenckii by broth microdilution technique
|
Sporothrix schenckii
|
1.45
ug.mL-1
|
|
|
Antifungal activity against Trichophyton mentagrophytes by broth microdilution technique
|
Arthroderma benhamiae
|
0.63
ug.mL-1
|
|
|
Antifungal activity against Candida albicans after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.13
ug.mL-1
|
|
|
Antifungal activity against Candida albicans MTCC 183 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.26
ug.mL-1
|
|
|
Antifungal activity against Candida albicans MTCC 1346 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.58
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.35
ug.mL-1
|
|
|
Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by broth micro dilution technique
|
Pichia kudriavzevii
|
1.38
ug.mL-1
|
|
|
Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth micro dilution technique
|
Candida parapsilosis
|
0.21
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 10453 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.63
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.1
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 66027 after 48 hrs by broth micro dilution technique
|
Candida albicans
|
0.18
ug.mL-1
|
|
|
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT colorimetric assay
|
Mus musculus
|
387.0
ug.mL-1
|
|
|
Antimicrobial activity against Candida albicans NCL1 by broth microdilution method
|
Candida albicans
|
4.0
ug.mL-1
|
|
|
Antimicrobial activity against Cryptococcus neoformans NCL2 by broth microdilution method
|
Cryptococcus neoformans
|
16.0
ug.mL-1
|
|
|
Antimicrobial activity against Benjaminiella poitrasii NCL3 by broth microdilution method
|
Benjaminiella poitrasii
|
16.0
ug.mL-1
|
|
|
Antimicrobial activity against Yarrowia lipolytica NCL4 by broth microdilution method
|
Yarrowia lipolytica
|
32.0
ug.mL-1
|
|
|
Antimicrobial activity against Fusarium oxysporum NCL5 by broth microdilution method
|
Fusarium oxysporum
|
4.0
ug.mL-1
|
|
|
Antifungal activity against azole-sensitive Candida albicans by broth microdilution assay
|
Candida albicans
|
0.12
ug.mL-1
|
|
|
Antifungal activity against azole-resistant Candida albicans by broth microdilution assay
|
Candida albicans
|
256.0
ug.mL-1
|
|
|
Antifungal activity against azole-resistant Candida glabrata by broth microdilution assay
|
Candida glabrata
|
256.0
ug.mL-1
|
|
|
Antifungal activity against azole-resistant Candida krusei by broth microdilution assay
|
Pichia kudriavzevii
|
128.0
ug.mL-1
|
|
|
Antifungal activity against fluconazole-susceptible Candida albicans isolate 1 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
0.1
ug.mL-1
|
|
|
Antifungal activity against fluconazole-resistant Candida albicans isolate 2 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
1.0
ug.mL-1
|
|
|
Antifungal activity against fluconazole-resistant Candida albicans isolate 5 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
7.5
ug.mL-1
|
|
|
Antifungal activity against fluconazole-resistant Candida albicans isolate 8 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
15.0
ug.mL-1
|
|
|
Antifungal activity against fluconazole-resistant Candida albicans isolate 17 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
40.0
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 1.25 ug/mL dihydrosphingosine
|
Candida albicans
|
0.3
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 2.5 ug/mL dihydrosphingosine
|
Candida albicans
|
0.5
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5.0 ug/mL dihydrosphingosine
|
Candida albicans
|
0.7
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5 ug/mL stearylamine
|
Candida albicans
|
0.65
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 15 ug/mL stearylamine
|
Candida albicans
|
0.8
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 30 ug/mL stearylamine
|
Candida albicans
|
0.75
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028 after 24 to 48 hrs by NCCLS method
|
Candida albicans
|
0.18
ug.mL-1
|
|
|
Antifungal activity against MDR knockout Candida albicans DSY1024 after 24 hrs by XTT assay
|
Candida albicans
|
6.7
ug.mL-1
|
|
|
Antifungal activity against wild type Candida albicans SC5314 after 24 hrs by XTT assay
|
Candida albicans SC5314
|
0.18
ug.mL-1
|
|
|
Antimicrobial activity against Candida albicans by broth microdilution method
|
Candida albicans
|
0.13
ug.mL-1
|
|
|
Antimicrobial activity against Cryptococcus neoformans by broth microdilution method
|
Cryptococcus neoformans
|
0.45
ug.mL-1
|
|
|
Antimicrobial activity against Sporothrix schenckii by broth microdilution method
|
Sporothrix schenckii
|
1.45
ug.mL-1
|
|
|
Antimicrobial activity against Trichophyton mentagrophytes by broth microdilution method
|
Trichophyton mentagrophytes
|
0.6
ug.mL-1
|
|
|
Antimicrobial activity against Aspergillus fumigatus by broth microdilution method
|
Aspergillus fumigatus
|
1.06
ug.mL-1
|
|
|
Antimicrobial activity against Candida parapsilosis ATCC 22019 by broth microdilution method
|
Candida parapsilosis
|
0.21
ug.mL-1
|
|
|
Antimicrobial activity against Candida albicans SC5314 at 512 ug/ml at planktonic cell density of 5 x 10'7 cells/ml after 48 hrs by XTT assay
|
Candida albicans
|
40.0
%
|
|
|
Antifungal activity against Candida albicans by broth microdilution test
|
Candida albicans
|
14.0
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans by broth microdilution test
|
Cryptococcus neoformans
|
16.0
ug.mL-1
|
|
|
Antifungal activity against Fusarium oxysporum by broth microdilution test
|
Fusarium oxysporum
|
4.0
ug.mL-1
|
|
|
Antifungal activity against Candida albicans after 48 hrs by microbroth dilution technique
|
Candida albicans
|
0.13
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution technique
|
Cryptococcus neoformans
|
0.46
ug.mL-1
|
|
|
Antifungal activity against Sporothrix schenckii after 72 hrs by microbroth dilution technique
|
Sporothrix schenckii
|
1.45
ug.mL-1
|
|
|
Antifungal activity against Trichophyton mentagrophytes after 96 hrs by microbroth dilution technique
|
Trichophyton mentagrophytes
|
0.6
ug.mL-1
|
|
|
Antifungal activity against Aspergillus fumigatus AF-27 after 72 hrs by microbroth dilution technique
|
Aspergillus fumigatus
|
1.06
ug.mL-1
|
|
|
Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microbroth dilution technique
|
Candida parapsilosis
|
0.21
ug.mL-1
|
|
|
Inhibition of polyhistidine tagged yeast prion protein Sup35 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid polymerization at 50 uM by thioflavin T fluorescence assay relative to untreated control
|
Saccharomyces cerevisiae
|
0.0
%
|
|
|
Inhibition of polyhistidine tagged yeast prion protein Sup35 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid polymerization at 50 uM in presence of 5 mg/ml BSA by thioflavin T fluorescence assay relative to untreated control
|
Saccharomyces cerevisiae
|
9.0
%
|
|
|
Inhibition of mouse prion protein (89-230) assessed as inhibition of amyloid polymerization at 50 uM by thioflavin T fluorescence assay relative to untreated control
|
Mus musculus
|
5.9
%
|
|
|
Antimicrobial activity against Aspergillus niger assessed as inhibition of mycelial growth by poisoned food method
|
Aspergillus niger
|
81.1
%
|
|
|
Antimicrobial activity against Aspergillus flavus assessed as inhibition of mycelial growth by poisoned food method
|
Aspergillus flavus
|
77.7
%
|
|
|
Antifungal activity against Candida albicans ATCC 3153 in vitro pharmacokinetic-pharmacodynamic model
|
Candida albicans
|
0.0929
ug.mL-1
|
|
|
Antifungal activity against Candida albicans CA8621 by spectrophotometry
|
Candida albicans
|
0.09
ug.mL-1
|
|
|
Antifungal activity against Aspergillus fumigatus AF4215 spectrophotometry
|
Aspergillus fumigatus
|
0.18
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans ATCC 66031 after 72 hrs by CLSI method
|
Cryptococcus neoformans
|
700.0
nM
|
|
|
Antifungal activity against Fluconazole resistant Candida albicans clinical isolate 1 after 48 hrs by CLSI method
|
Candida albicans
|
800.0
nM
|
|
|
Antifungal activity against Candida albicans ATCC 200955 after 48 hrs by CLSI method
|
Candida albicans
|
400.0
nM
|
|
|
Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by CLSI method
|
Candida albicans
|
800.0
nM
|
|
|
Binding affinity to Candida albicans CYP56 by spectrophotometry
|
Candida albicans
|
230.0
nM
|
|
|
Antifungal activity against Candida albicans ATCC 32354 after 48 hrs by CLSI method
|
Candida albicans
|
800.0
nM
|
|
|
Antifungal activity against Candida albicans ATCC 14053 after 48 hrs by CLSI method
|
Candida albicans
|
500.0
nM
|
|
|
Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by CLSI method
|
Candida albicans
|
400.0
nM
|
|
|
Binding affinity to Mycobacterium tuberculosis CYP51
|
Mycobacterium tuberculosis
|
200.0
nM
|
|
|
Binding affinity to Candida albicans CYP51
|
Candida albicans
|
45.0
nM
|
|
|
Antifungal activity against Aspergillus niger MTCC 282 assessed as inhibition of mycelial growth for 7 days by poisoned food method
|
Aspergillus niger
|
75.3
%
|
|
|
Antifungal activity against Aspergillus flavus MTCC 871 assessed as inhibition of mycelial growth for 7 days by poisoned food method
|
Aspergillus flavus
|
74.6
%
|
|
|
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting
|
Homo sapiens
|
7.4
%
|
|
|
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
7.5
%
|
|
|
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
34.1
%
|
|
|
Antimicrobial activity against Candida albicans assessed as growth inhibition after 24 hr by serial double dilution method
|
Candida albicans
|
980.0
nM
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
86.64
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
106.49
%
|
|
|
Antifungal activity against Candida albicans MTCC 183 after 48 hrs by broth microdilution technique
|
Candida albicans
|
0.21
ug.mL-1
|
|
|
Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution technique
|
Candida parapsilosis
|
0.46
ug.mL-1
|
|
|
Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique
|
Candida albicans
|
0.13
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique
|
Cryptococcus neoformans
|
0.46
ug.mL-1
|
|
|
Antifungal activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique
|
Aspergillus fumigatus
|
0.38
ug.mL-1
|
|
|
Antifungal activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique
|
Trichophyton mentagrophytes
|
0.06
ug.mL-1
|
|
|
Antifungal activity against Sporothrix schenckii after 48 hrs by broth microdilution technique
|
Sporothrix schenckii
|
0.08
ug.mL-1
|
|
|
Antimicrobial activity against Candida glabrata by Alamar blue method
|
Candida glabrata
|
27.0
ug.mL-1
|
|
|
Antimicrobial activity against Candida krusei ATCC 6258 by Alamar blue method
|
Pichia kudriavzevii
|
27.0
ug.mL-1
|
|
|
Antimicrobial activity against Cryptococcus neoformans ATCC 90113 by Alamar blue method
|
Cryptococcus neoformans
|
0.21
ug.mL-1
|
|
|
Antimicrobial activity against Candida albicans ATCC 90028 by Alamar blue method
|
Candida albicans
|
0.12
ug.mL-1
|
|
|
Binding affinity to Trypanosoma cruzi CYP51
|
Trypanosoma cruzi
|
230.0
nM
|
|
|
Cytotoxicity against human HepG2 cells after 2 days by MTT assay
|
Homo sapiens
|
250.0
ug.mL-1
|
|
|
Anticandidal activity against Candida albicans ATCC 90028 incubated at 37 degC for 24 hrs by broth dilution method
|
Candida albicans
|
15.62
ug.mL-1
|
|
|
Anticandidal activity against Candida glabrata ATCC 90030 incubated at 37 degC for 24 hrs by broth dilution method
|
Candida glabrata
|
7.81
ug.mL-1
|
|
|
Anticandidal activity against Candida tropicalis ATCC 750 incubated at 37 degC for 24 hrs by broth dilution method
|
Candida tropicalis
|
8.55
ug.mL-1
|
|
|
Binding affinity to recombinant full-length Trypanosoma cruzi CYP51 by UV-spectrophotometric analysis
|
Trypanosoma cruzi
|
230.0
nM
|
|
|
Inhibition of CYP2C9 (unknown origin) at 120 uM by luminescent readout-based method
|
Homo sapiens
|
89.09
%
|
|
|
Antifungal activity against Candida albicans ATCC 10231 at 10 ug/ml after 48 hrs by cup plate method
|
Candida albicans
|
12.5
%
|
|
|
Antifungal activity against Candida albicans ATCC 10231 at 50 ug/ml after 48 hrs by cup plate method
|
Candida albicans
|
30.0
%
|
|
|
Antifungal activity against Candida albicans ATCC 10231 at 100 ug/ml after 48 hrs by cup plate method
|
Candida albicans
|
65.55
%
|
|
|
Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 10 ug/ml after 18 hrs by UV spectroscopy analysis
|
Candida albicans
|
45.45
%
|
|
|
Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 50 ug/ml after 18 hrs by UV spectroscopy analysis
|
Candida albicans
|
47.67
%
|
|
|
Inhibition of Candida albicans lanosterol 14-alpha demethylase assessed as reduction of ergosterol biosynthesis at 100 ug/ml after 18 hrs by UV spectroscopy analysis
|
Candida albicans
|
51.16
%
|
|
|
Antifungal activity against Candida albicans SC5314 assessed as inhibition of biofilm formation by XTT assay
|
Candida albicans SC5314
|
2.0
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 24433 after 24 to 36 hrs by broth microdilution method
|
Candida albicans
|
0.73
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 10231 after 24 to 36 hrs by broth microdilution method
|
Candida albicans
|
4.21
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans ATCC 34664 after 24 to 36 hrs by broth microdilution method
|
Cryptococcus neoformans
|
4.6
ug.mL-1
|
|
|
Antifungal activity against Candida glabrata NCYC 388 after 24 to 36 hrs by broth microdilution method
|
Candida glabrata
|
16.0
ug.mL-1
|
|
|
Antifungal activity against Candida tropicalis ATCC 750 after 24 to 36 hrs by broth microdilution method
|
Candida tropicalis
|
64.0
ug.mL-1
|
|
|
Antifungal activity against Aspergillus niger ATCC 10578 after 48 hrs by broth microdilution method
|
Aspergillus niger
|
256.0
ug.mL-1
|
|
|
Cytotoxicity against human HeLa cells after 48 hrs by SRB assay
|
Homo sapiens
|
100.0
ug.mL-1
|
|
|
Inhibition of CYP2C9 (unknown origin) at 120 uM by P450-glo assay
|
Homo sapiens
|
89.09
%
|
|
|
Inhibition of Candida albicans keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control
|
Candida albicans
|
61.3
%
|
|
|
Inhibition of Microsporum gypseum keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control
|
Nannizzia gypsea
|
61.3
%
|
|
|
Inhibition of Trichophyton mentagrophytes keratinase activity at MIC incubated for 5 days under non-shaking condition and subsequent incubation for 5 days under shaking condition by UV-vis spectrophotometric analysis relative to control
|
Trichophyton mentagrophytes
|
61.3
%
|
|
|
Antibiofilm activity against Candida albicans assessed inhibition of biofilm formation at 1024 ug/ml
|
Candida albicans
|
60.0
%
|
|
|
Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growth by fluorescence based analysis
|
Trypanosoma cruzi
|
880.0
nM
|
|
|
Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans serotype A H99 at pH 7 measured over 4 days
|
Cryptococcus neoformans var. grubii H99
|
950.0
nM
|
|
|
Antifungal activity against wild-type fluconazole-sensitive Cryptococcus neoformans serotype D B3501 measured over 4 days
|
Cryptococcus neoformans
|
130.0
nM
|
|
|
Inhibition of ergosterol biosynthesis in fluconazole resistant Candida albicans A171 at 8 ug/ml relative to control
|
Candida albicans
|
11.0
%
|
|
|
Inhibition of ergosterol biosynthesis in fluconazole susceptible Candida albicans ATCC 90028 at 8 ug/ml relative to control
|
Candida albicans
|
100.0
%
|
|
|
Cytotoxicity against human A549 cells by MTT assay
|
Homo sapiens
|
100.0
ug.mL-1
|
|
|
Cytotoxicity against human HepG2 cells by MTT assay
|
Homo sapiens
|
100.0
ug.mL-1
|
|
|
Cytotoxicity against human HT-29 cells by MTT assay
|
Homo sapiens
|
100.0
ug.mL-1
|
|
|
Cytotoxicity against rat H9c2 cells by MTT assay
|
Rattus norvegicus
|
100.0
ug.mL-1
|
|
|
Toxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
|
Homo sapiens
|
62.5
ug.mL-1
|
|
|
Toxicity in human BEAS2B cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
|
Homo sapiens
|
62.5
ug.mL-1
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
5.22
%
|
|
|
Inhibition of fatty acid synthase in Trichophyton rubrum ATCC MYA3108
|
Trichophyton rubrum
|
68.23
ug.mL-1
|
|
|
Antimicrobial activity against Candida albicans ATCC 90028 assessed as inhibition of microbial growth by CLSI based method
|
Candida albicans
|
1.0
nM
|
|
|
Antimicrobial activity against Aspergillus fumigatus ATCC 90906 assessed as inhibition of microbial growth by CLSI based method
|
Aspergillus fumigatus
|
300.0
nM
|
|
|
Antimicrobial activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of microbial growth by CLSI based method
|
Cryptococcus neoformans
|
5.0
nM
|
|
|
Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of microbial growth by CLSI based method
|
Staphylococcus aureus
|
300.0
nM
|
|
|
Antimicrobial activity against Escherichia coli ATCC 35218 assessed as inhibition of microbial growth by CLSI based method
|
Escherichia coli
|
300.0
nM
|
|
|
Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of microbial growth by CLSI based method
|
Pseudomonas aeruginosa
|
300.0
nM
|
|
|
Inhibition of biofilm formation in azole resistant Candida albicans 0304103 at 64 ug/ml after 24 hrs by XTT assay relative to control
|
Candida albicans
|
22.9
%
|
|
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay relative to control
|
Homo sapiens
|
40.0
%
|
|
|
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by XTT assay relative to control
|
Homo sapiens
|
40.0
%
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
0.8772
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
|
Antibiofilm activity against Candida albicans NR29448 assessed as reduction in biofilm formation at 0.5XMIC incubated for 24 hrs by crystal violet staining based assay relative to control
|
Candida albicans
|
50.0
%
|
|
|
Inhibition of Candida albicans ATCC SC5314 CYP51 incubated for 30 mins by spectrophotometric method
|
Candida albicans SC5314
|
116.0
nM
|
|
|
Inhibition of ergosterol biosynthesis in Cryptococcus neoformans PFCC 93-589 cell membrane at 0.5 times MIC incubated for 48 hrs by UV-visible spectrophotometric analysis
|
Cryptococcus neoformans
|
58.95
%
|
|
|
Inhibition of ergosterol biosynthesis in Cryptococcus neoformans PFCC 93-589 cell membrane at 1 times MIC incubated for 48 hrs by UV-visible spectrophotometric analysis
|
Cryptococcus neoformans
|
64.92
%
|
|
|
Antifungal activity against Candida albicans CAAL93 assessed as reduction in fungal growth
|
Candida albicans
|
300.0
nM
|
|
|
Induction of drug resistance in Candida albicans ATCC SC5314 assessed as increase in FCZ IC50 at 8 times IC50 measured after 5 to 22 days
|
Candida albicans
|
64.0
ug.mL-1
|
|
|
Induction of drug resistance in Candida glabrata BG2 assessed as increase in FCZ IC50 at 8 times IC50 after 23 days
|
Candida glabrata
|
64.0
ug.mL-1
|
|
|
Inhibition of CYP51 in Candida albicans ATCC SC5314 measured after 30 mins by HPLC analysis
|
Candida albicans
|
134.0
nM
|
|
|
Inhibition of CYP51 in Candida albicans SC5314 assessed as lanosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis
|
Candida albicans
|
15.13
%
|
|
|
Inhibition of CYP51 in Candida albicans SC5314 assessed as ergosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis (Rvb = 100%)
|
Candida albicans
|
34.28
%
|
|
|
Inhibition of CYP51 in Candida albicans SC5314 assessed as eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis
|
Candida albicans
|
7.57
%
|
|
|
Inhibition of CYP51 in Candida albicans SC5314 assessed as 140-methy lergosta-8,24(28)-dien-3(3,60-diol (4) level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis
|
Candida albicans
|
30.66
%
|
|
|
Inhibition of CYP51 in Candida albicans SC5314 assessed as unknown sterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis
|
Candida albicans
|
1.92
%
|
|
