None is not found in the database.

ETHOPROPAZINE HYDROCHLORIDE

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Search structure


Trade Names	PARSIDOL
Synonyms	Ethopropazine hcl Ethopropazine hydrochloride NSC-169467 NSC-64074 Parsidol Profenamine Profenamine hibenzate Profenamine hydrochloride Prophenamine hydrochloride
Status
Molecule Category	Salt-form
UNII	O00T1I1VRN
EPA CompTox	DTXSID4045347

Structure


InChI Key	VXPCQISYVPFYRK-UHFFFAOYSA-N
Smiles	CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21.Cl
InChI	InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H25ClN2S
Molecular Weight	348.94
AlogP	5.02
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	6.48
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Muscarinic acetylcholine receptor M1 antagonist	ANTAGONIST	ISBN PubMed Wikipedia Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	60.6-85.68

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	60.6-85.68

Target Conservation


Protein: Muscarinic acetylcholine receptor M1 Description: Muscarinic acetylcholine receptor M1 Organism : Homo sapiens P11229 ENSG00000168539

Cross References

Resources	Reference
ChEBI	31568
ChEMBL	CHEMBL1200970
FDA SRS	O00T1I1VRN
Guide to Pharmacology	7181
KEGG	D08426
PubChem	3290
SureChEMBL	SCHEMBL123703
ZINC	ZINC00056651

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025