EPINEPHRINE


Trade Names	ADRENACLICK ADRENALIN AUVI-Q BRONKAID MIST EPI E Z PEN JR EPINEPHRINE EPINEPHRINE (AUTOINJECTOR) EPIPEN EPIPEN E Z PEN EPIPEN JR. PRIMATENE MIST SUS-PHRINE SULFITE FREE SYMJEPI TWINJECT 0.15 TWINJECT 0.3
Synonyms	(-)-(r)-epinephrine (-)-epinephrine Adren co Adrenaclick Adrenalin Adrenaline Adrenalinum Ana-Kit Ana-guard Anapen Anaphylactic shock drug kit Asma-vydrin Asthmahaler Auvi-q Bronkaid mist
Status
Molecule Category	Free-form
ATC	A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
UNII	YKH834O4BH
EPA CompTox	DTXSID5022986


InChI Key	UCTWMZQNUQWSLP-VIFPVBQESA-N
Smiles	CNC[C@H](O)c1ccc(O)c(O)c1
InChI	InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

Property Name	Value
Molecular Formula	C9H13NO3
Molecular Weight	183.21
AlogP	0.35
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	3.0
Polar Surface Area	72.72
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	13.0

Mechanism of Action	Action	Reference
Adrenergic receptor agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	15-436	8-17	630-630.96	5-720	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	-	910	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	29.1

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	15-436	-	-	5	-
Homo sapiens	30.2-300	-	630-630.96	100-910	29.1
Rattus norvegicus	230	-	-	38-160	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	28918
ChEMBL	CHEMBL679
DrugBank	DB00668
DrugCentral	1028
FDA SRS	YKH834O4BH
Human Metabolome Database	HMDB0000068
Guide to Pharmacology	479
KEGG	C00788
PDB	ALE
PharmGKB	PA449470
PubChem	5816
SureChEMBL	SCHEMBL3814
ZINC	ZINC000000039089

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

EPINEPHRINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References