EPINASTINE HYDROCHLORIDE

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Search structure


Trade Names	ELESTAT EPINASTINE HYDROCHLORIDE
Synonyms	Alesion DE-114 Elestat Epinastine HCl Epinastine hcl Epinastine hydrochloride Relestat WAL 801 CL WAL-801CL WAL-802-CL
Status
Molecule Category	Salt-form
UNII	GFM415S5XL
EPA CompTox	DTXSID1046502
Parent Compound:	EPINASTINE

Structure


InChI Key	VKXSGUIOOQPGAF-UHFFFAOYSA-N
Smiles	Cl.NC1=NCC2c3ccccc3Cc3ccccc3N12
InChI	InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H16ClN3
Molecular Weight	285.78
AlogP	2.47
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Polar Surface Area	41.62
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	19.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	Wikipedia FDA

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	51037
ChEMBL	CHEMBL1200491
FDA SRS	GFM415S5XL
Guide to Pharmacology	7176
KEGG	D07900
PubChem	157313
SureChEMBL	SCHEMBL122749
ZINC	ZINC01999487

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025