EcoDrugPlus


Trade Names	ELTROMBOPAG
Synonyms	Eltrombopag Revolade SB497115
Status
Molecule Category	Free-form
ATC	B02BX05
UNII	S56D65XJ9G


InChI Key	XDXWLKQMMKQXPV-QYQHSDTDSA-N
Smiles	CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O
InChI	InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

Property Name	Value
Molecular Formula	C25H22N4O4
Molecular Weight	442.48
AlogP	4.56
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	114.59
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	33.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	630.96-690	-	-	-
Membrane receptor	38-38	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	38-38	690	-	-	-

Resources	Reference
ChEBI	85010
ChEMBL	CHEMBL461101
DrugBank	DB06210
DrugCentral	4399
FDA SRS	S56D65XJ9G
Guide to Pharmacology	6961
SureChEMBL	SCHEMBL211081
ZINC	ZINC000011679756

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ELTROMBOPAG

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Physicochemical Descriptors

Pharmacology

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