DIPHENYLPYRALINE HYDROCHLORIDE

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Search structure


Trade Names	HISPRIL
Synonyms	Diphenylpyraline HCl Diphenylpyraline hcl Diphenylpyraline hydrochloride Diphenylpyraline teoclate Hispril Histryl Histryl paed Lergoban NSC-61825
Status
Molecule Category	Salt-form
UNII	G9FU7F1E87
EPA CompTox	DTXSID7047772

Structure


InChI Key	LPRLDRXGWKXRMQ-UHFFFAOYSA-N
Smiles	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1.Cl
InChI	InChI=1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H24ClNO
Molecular Weight	317.86
AlogP	3.89
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	12.47
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	68.46-87.39

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	68.46-87.39
Mycobacterium tuberculosis	-	-	-	-	5

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	31508
ChEMBL	CHEMBL1564
FDA SRS	G9FU7F1E87
Guide to Pharmacology	7165
KEGG	D07862
PubChem	66063
SureChEMBL	SCHEMBL212198
ZINC	ZINC00056643

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025