DIETHYLPROPION HYDROCHLORIDE

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Search structure


Trade Names	DIETHYLPROPION HYDROCHLORIDE TENUATE TENUATE DOSPAN TEPANIL TEPANIL TEN-TAB
Synonyms	Amfepramone hydrochloride Anorex Apisate D03801 Diethylpropion HCl Diethylpropion hcl Diethylpropion hydrochloride Diethylpropion hydrochloride civ Dobesin Moderatan Prefamone Regenon Tenuate Tenuate dospan Tepanil
Status
Molecule Category	Salt-form
UNII	19V2PL39NG
EPA CompTox	DTXSID4047838

Structure


InChI Key	ICFXZZFWRWNZMA-UHFFFAOYSA-N
Smiles	CCN(CC)C(C)C(=O)c1ccccc1.Cl
InChI	InChI=1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C13H20ClNO
Molecular Weight	241.76
AlogP	2.6
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	20.31
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine transporter inhibitor	INHIBITOR	ISBN PubMed PubMed DailyMed

Target Conservation


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319

Cross References

Resources	Reference
ChEBI	643703
ChEMBL	CHEMBL1693
FDA SRS	19V2PL39NG
PubChem	91442
SureChEMBL	SCHEMBL15483

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025