DIDANOSINE


Trade Names	DIDANOSINE VIDEX VIDEX EC
Synonyms	(-)-didanosine BMY-40900 Ddi Didanosine Didanosine system suitability mixture Didanosinum Dideoxyinosine (ddi) NSC-612049 Videx Videx ec
Status
Molecule Category	Free-form
ATC	J05AF02
UNII	K3GDH6OH08
EPA CompTox	DTXSID6022927


InChI Key	BXZVVICBKDXVGW-NKWVEPMBSA-N
Smiles	O=c1[nH]cnc2c1ncn2[C@H]1CC[C@@H](CO)O1
InChI	InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

Property Name	Value
Molecular Formula	C10H12N4O3
Molecular Weight	236.23
AlogP	-0.21
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	93.03
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	17.0

Mechanism of Action	Action	Reference
Human immunodeficiency virus type 1 reverse transcriptase inhibitor	INHIBITOR	DailyMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	900	300	-	-	-
Human immunodeficiency virus 1	5.6-5.6	100-490	-	-	-
Rattus norvegicus	-	-	-	-	48

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
South Africa

Resources	Reference
ChEBI	490877
ChEMBL	CHEMBL1460
DrugBank	DB00900
DrugCentral	869
FDA SRS	K3GDH6OH08
Human Metabolome Database	HMDB0015037
Guide to Pharmacology	4833
KEGG	C06953
PDB	2DI
PharmGKB	PA449301
PubChem	135398739
SureChEMBL	SCHEMBL3363
ZINC	ZINC000013597823

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

DIDANOSINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Environmental Exposure

Cross References