|
50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes
|
None
|
40.0
nM
|
|
|
In vitro inhibition of human Carbonic Anhydrase II
|
None
|
40.0
nM
|
|
|
Inhibitory activity of compound against human carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II was determined
|
None
|
38.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase II
|
None
|
40.0
nM
|
|
|
Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C
|
None
|
38.0
nM
|
|
|
In vitro inhibitory activity against human carbonic anhydrase II (hCAII)
|
None
|
38.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II)
|
None
|
38.0
nM
|
|
|
Inhibitory activity against Human carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase II (hCA II)
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.
|
None
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)
|
None
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
38.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
|
None
|
38.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase II (CA2)
|
None
|
38.0
nM
|
|
|
Inhibitory activity of compound against bovine carbonic anhydrase IV
|
None
|
380.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV was determined
|
None
|
380.0
nM
|
|
|
Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C
|
None
|
380.0
nM
|
|
|
In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)
|
None
|
380.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes
|
None
|
380.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV
|
None
|
380.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)
|
None
|
380.0
nM
|
|
|
Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes
|
None
|
380.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.
|
None
|
380.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes
|
None
|
380.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes
|
None
|
380.0
nM
|
|
|
Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes
|
None
|
380.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV)
|
None
|
380.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX was determined
|
None
|
50.0
nM
|
|
|
Inhibition constant evaluated for the inhibition of human CA IX (Carbonic anhydrase IX)
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.
|
None
|
50.0
nM
|
|
|
Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX
|
None
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
|
None
|
50.0
nM
|
|
|
Inhibition of murine mitochondrial isozyme Carbonic anhydrase V at 20 degrees C
|
None
|
640.0
nM
|
|
|
Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
|
None
|
23.0
nM
|
|
|
Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Ki value against human carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Ki value against human carbonic anhydrase VII
|
Homo sapiens
|
26.5
nM
|
|
|
Ratio against Carbonic anhydrase II to Carbonic anhydrase IX
|
Homo sapiens
|
0.76
Ratio
|
|
|
Ki value against human carbonic anhydrase II (hCA II)
|
Homo sapiens
|
38.0
nM
|
|
|
Ki value against murine carbonic anhydrase XIII
|
Mus musculus
|
23.0
nM
|
|
|
Ki value against human carbonic anhydrase XII (hCA XII)
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition constant against human carbonic anhydrase XII
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCAII)
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)
|
Bos taurus
|
380.0
nM
|
|
|
Inhibitory activity against cytosolic human carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Binding affinity towards human cloned carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
150.0
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
190.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21
|
Homo sapiens
|
25.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
|
Homo sapiens
|
8.0
nM
|
|
|
Inhibitory activity against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21
|
Homo sapiens
|
34.0
nM
|
|
|
Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against human recombinant cytosolic CA2
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VA
|
Homo sapiens
|
630.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VB
|
Homo sapiens
|
21.0
nM
|
|
|
Inhibitory activity against cloned human CA2
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibitory activity against CA4 isolated from bovine lung microsomes
|
Bos taurus
|
380.0
nM
|
|
|
Inhibitory activity against cloned human CA9
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibitory activity against cloned human CA12
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
|
Helicobacter pylori
|
378.0
nM
|
|
|
Inhibition of human recombinant CA2
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Helicobacter pylori recombinant CA
|
Helicobacter pylori
|
363.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned CA9 catalytic domain by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned CA2 by stopped-flow CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned CA5A by stopped-flow CO2 hydration method
|
Homo sapiens
|
630.0
nM
|
|
|
Inhibition of human cloned CA5B by stopped-flow CO2 hydration method
|
Homo sapiens
|
21.0
nM
|
|
|
Inhibition of human cloned CA7 by stopped-flow CO2 hydration method
|
Homo sapiens
|
26.0
nM
|
|
|
Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of murine CA13 by stopped-flow CO2 hydration method
|
Mus musculus
|
23.0
nM
|
|
|
Inhibition of human cloned CA14 by stopped-flow CO2 hydration method
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of full length human recombinant CA VI
|
Homo sapiens
|
79.0
nM
|
|
|
Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant CA IX
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant isozyme CA2 by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA12 by CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA14 by CO2 hydration assay
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned catalytic domain CA9 by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5A
|
Homo sapiens
|
630.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5B
|
Homo sapiens
|
21.0
nM
|
|
|
Inhibition of human carbonic anhydrase 6
|
Homo sapiens
|
79.0
nM
|
|
|
Inhibition of human carbonic anhydrase 7
|
Homo sapiens
|
26.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of mouse carbonic anhydrase 13
|
Mus musculus
|
23.0
nM
|
|
|
Inhibition of human carbonic anhydrase 14
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human CA9 catalytic domain by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
374.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
95.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay
|
Homo sapiens
|
81.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay
|
Homo sapiens
|
91.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
134.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
6.0
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
872.0
nM
|
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis H37Rv
|
611.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
|
Saccharomyces cerevisiae
|
103.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
79.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
|
Mus musculus
|
95.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis H37Rv recombinant beta-carbonic anhydrase 1 expressed in Escherichia coli BL21 by stopped flow CO2 hydration method
|
Mycobacterium tuberculosis H37Rv
|
872.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay
|
Candida albicans
|
910.0
nM
|
|
|
Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay
|
Candida albicans
|
909.0
nM
|
|
|
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
38.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
|
Stylophora pistillata
|
431.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method
|
Homo sapiens
|
630.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method
|
Homo sapiens
|
21.0
nM
|
|
|
Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method
|
Homo sapiens
|
79.0
nM
|
|
|
Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method
|
Homo sapiens
|
26.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method
|
Mus musculus
|
23.0
nM
|
|
|
Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method
|
Mus musculus
|
95.0
nM
|
|
|
Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
79.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
431.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
79.0
nM
|
|
|
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3
|
Brucella suis
|
112.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3
|
Brucella suis
|
58.0
nM
|
|
|
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
630.0
nM
|
|
|
Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
21.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5
|
Leptonychotes weddellii
|
513.0
nM
|
|
|
Inhibition of human CA2 by CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
26.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
23.0
nM
|
|
|
Inhibition of human full length cytosolic isoform of carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 1 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
90.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 2 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
95.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
345.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Astrosclera willeyana
|
62.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Candida albicans
|
909.0
nM
|
|
|
Inhibition of GST-tagged Malassezia globosa ATCC 96807/CBS 7966 MG-CA expressed in Escherichia coli BL21(DE3) cells preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Malassezia globosa CBS 7966
|
346.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Vibrio cholerae
|
37.1
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay
|
Trypanosoma cruzi
|
128.0
nM
|
|
|
Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Candida glabrata
|
112.0
nM
|
|
|
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Sulfurihydrogenibium yellowstonense
|
8.5
nM
|
|
|
Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Helicobacter pylori
|
378.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Leishmania donovani chagasi beta-carbonic anhydrase expressed in baculovirus infected insect Sf9 cells incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leishmania donovani chagasi
|
189.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
26.5
nM
|
|
|
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Thalassiosira weissflogii
|
458.0
nM
|
|
|
Inhibition of Leishmania donovani chagasi recombinant beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Leishmania chagasi
|
189.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-CA CAM by stopped flow CO2 hydration assay
|
Leishmania donovani chagasi
|
190.0
nM
|
|
|
Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
64.1
nM
|
|
|
Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
105.0
nM
|
|
|
Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay
|
Plasmodium falciparum
|
542.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Methanosarcina thermophila
|
190.0
nM
|
|
|
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Nostoc commune
|
345.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Anopheles gambiae
|
630.0
nM
|
|
|
Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay
|
Nostoc commune
|
345.0
nM
|
|
|
Inhibition of Methanosarcina thermophila recombinant gamma carbonic anhydrase by stopped flow CO2 hydrase assay method
|
Methanosarcina thermophila
|
190.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Sulfurihydrogenibium yellowstonense
|
8.5
nM
|
|
|
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Thiomicrospira crunogena XCL-2
|
24.8
nM
|
|
|
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
37.1
nM
|
|
|
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Nostoc commune
|
345.0
nM
|
|
|
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Colwellia psychrerythraea
|
639.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Enterobacter sp.
|
938.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of Burkholderia pseudomallei beta-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Burkholderia pseudomallei
|
529.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of recombinant human full-length carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
50.0
nM
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
-5.31
%
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
38.0
nM
|
|
|
Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase (181 to 538 residues) expressed in Escherichia coli artic express (DE3) preincubated for 15 mins by stop flow CO2 hydrase assay
|
Plasmodium falciparum
|
890.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
10.85
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
8.49
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.08
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.08
%
|
|
