DIAZOXIDE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC C02DA01 V03AH01
UNII O5CB12L4FN
EPA CompTox DTXSID7022914

Structure

InChI Key GDLBFKVLRPITMI-UHFFFAOYSA-N
Smiles CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InChI
InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H7ClN2O2S
Molecular Weight 230.68
AlogP 1.87
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Polar Surface Area 58.53
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Mechanism of Action Action Reference
Potassium channel, inwardly rectifying, subfamily J, member 11 opener OPENER ISBN DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 12.8
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 91.61-91.81
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cavia porcellus
- - - - 12.8
Cricetulus griseus
- - - - 91.61-91.81
Rattus norvegicus
- - - - 53-91

Cross References

Resources Reference
ChEBI 4495
ChEMBL CHEMBL181
DrugBank DB01119
DrugCentral 854
FDA SRS O5CB12L4FN
Human Metabolome Database HMDB0015251
Guide to Pharmacology 2409
KEGG C06949
PDB 20J
PharmGKB PA449285
PubChem 3019
SureChEMBL SCHEMBL41254
ZINC ZINC000003872277
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