DEXTROTHYROXINE SODIUM

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Search structure


Trade Names	CHOLOXIN
Synonyms	Anhydrous dextrothyroxine sodium Choloxin D-thyroxine sodium salt Dextrothyroxine sodium Dextrothyroxine sodium anhydrous Dextrothyroxine sodium hydrate Monosodium d-thyroxine hydrate Sodium dextrothyroxine
Status
Molecule Category	Salt-form
UNII	0H00N2AHSP
EPA CompTox	DTXSID60220803

Structure


InChI Key	ANMYAHDLKVNJJO-CURYUGHLSA-M
Smiles	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+]
InChI	InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m1../s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H12I4NNaO5
Molecular Weight	816.87
AlogP	4.56
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	92.78
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	24.0

Pharmacology

Mechanism of Action	Action	Reference
Thyroid hormone receptor agonist	AGONIST	ISBN PubMed PubMed

Cross References

Resources	Reference
ChEMBL	CHEMBL3545058
FDA SRS	0H00N2AHSP
PubChem	23677961
SureChEMBL	SCHEMBL7112166

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025