DEXMEDETOMIDINE HYDROCHLORIDE

/static/temp/default.svg

Search structure


Trade Names	DEXMEDETOMIDINE HYDROCHLORIDE PRECEDEX
Synonyms	Cepedex Dexdomitor Dexdor Dexmedetomidine hcl Dexmedetomidine hydrochloride Precedex Sedadex Sileo
Status
Molecule Category	Salt-form
UNII	1018WH7F9I
EPA CompTox	DTXSID40873215
Parent Compound:	DEXMEDETOMIDINE

Structure


InChI Key	VPNGEIHDPSLNMU-MERQFXBCSA-N
Smiles	Cc1cccc([C@H](C)c2c[nH]cn2)c1C.Cl
InChI	InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C13H17ClN2
Molecular Weight	236.75
AlogP	3.18
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	28.68
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	15.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-2 agonist	AGONIST	DailyMed

Target Conservation


Protein: Adrenergic receptor alpha-2 Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha-2 Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286











Protein: Adrenergic receptor alpha-2 Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160

Cross References

Resources	Reference
ChEBI	31472
ChEMBL	CHEMBL2106195
FDA SRS	1018WH7F9I
KEGG	C07450
PubChem	6918081
SureChEMBL	SCHEMBL406837
ZINC	ZINC04632106

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025