DAPIPRAZOLE HYDROCHLORIDE

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Search structure


Trade Names	DAPIPRAZOLE HYDROCHLORIDE
Synonyms	AF 2139 AF-2139 Dapiprazole hcl Dapiprazole hydrochloride Dapiprazole monohydrochloride Rev-eyes
Status
Molecule Category	Salt-form
UNII	DS9UJN1I0X
EPA CompTox	DTXSID7048669

Structure


InChI Key	ZIODNPFQZIHCOE-UHFFFAOYSA-N
Smiles	Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1.Cl
InChI	InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19;/h2-3,6-7H,4-5,8-15H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H28ClN5
Molecular Weight	361.92
AlogP	2.29
Hydrogen Bond Acceptor	5.0
Number of Rotational Bond	4.0
Polar Surface Area	37.19
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	24.0

Pharmacology

Mechanism of Action	Action	Reference
Alpha-1a adrenergic receptor antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Alpha-1a adrenergic receptor Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907

Cross References

Resources	Reference
ChEMBL	CHEMBL1201044
FDA SRS	DS9UJN1I0X
PubChem	6917787
SureChEMBL	SCHEMBL667604

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025