DALFAMPRIDINE

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Trade Names
Synonyms
Status
Molecule Category Free-form
UNII BH3B64OKL9
EPA CompTox DTXSID0023870

Structure

InChI Key NUKYPUAOHBNCPY-UHFFFAOYSA-N
Smiles Nc1ccncc1
InChI
InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

Physicochemical Descriptors

Property Name Value
Molecular Formula C5H6N2
Molecular Weight 94.12
AlogP 0.66
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Polar Surface Area 38.91
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 7.0

Pharmacology

Mechanism of Action Action Reference
Voltage-gated potassium channel blocker BLOCKER FDA PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 1.2-3.8
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cavia porcellus
- - - - 1.2-3.8

Cross References

Resources Reference
ChEBI 34385
ChEMBL CHEMBL284348
DrugBank DB06637
DrugCentral 4163
FDA SRS BH3B64OKL9
Guide to Pharmacology 2416
KEGG C13728
PDB 4AP
PharmGKB PA166123389
PubChem 1727
SureChEMBL SCHEMBL53483
ZINC ZINC000000599985
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